Xuehui Liu1,2, Jianping Zhang1,2, Zhaowei Meng3, Qiang Jia2, Jian Tan2, Guizhi Zhang2, Xue Li2, Na Liu1,2, Tianpeng Hu2, Pingping Zhou2, Qing Zhang4, Kun Song4, Qiyu Jia4. 1. Department of Nuclear Medicine, Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Jintang Road No. 83, Hedong District, Tianjin, 300170, People's Republic of China. 2. Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin, 300052, People's Republic of China. 3. Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin, 300052, People's Republic of China. jamesmencius@163.com. 4. Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Abstract
OBJECTIVE: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. METHODS: We recruited 103 male and 254 female patients with Graves' hyperthyroidism, as well as the same number of control subjects. Anthropometric measurements and fasting blood tests were collected and analyzed statistically by binary logistic regressions to determine the risk of developing hyperuricemia in hyperthyroidism. RESULTS: SUA levels in males were significantly higher than that in females in both patients and controls. SUA levels were also significantly increased in hyperthyroid patients compared to in controls in both genders. The incidence of hyperuricemia rose significantly in subjects with hyperthyroidism with a higher prevalence in males than in females. SUA was negatively correlated with age and fasting glucose in male hyperthyroid patients, while it was positively correlated with body height, body weight, free triiodothyronine, and free thyroxine in female patients. Hyperthyroidism was a risk factor for hyperuricemia with an odd ratio of 4.536 for men and 2.730 for women. CONCLUSIONS: For hyperuricemia, hyperthyroidism was an important risk factor that should not be neglected, especially for men.
OBJECTIVE: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. METHODS: We recruited 103 male and 254 female patients with Graves' hyperthyroidism, as well as the same number of control subjects. Anthropometric measurements and fasting blood tests were collected and analyzed statistically by binary logistic regressions to determine the risk of developing hyperuricemia in hyperthyroidism. RESULTS:SUA levels in males were significantly higher than that in females in both patients and controls. SUA levels were also significantly increased in hyperthyroidpatients compared to in controls in both genders. The incidence of hyperuricemia rose significantly in subjects with hyperthyroidism with a higher prevalence in males than in females. SUA was negatively correlated with age and fasting glucose in male hyperthyroidpatients, while it was positively correlated with body height, body weight, free triiodothyronine, and free thyroxine in female patients. Hyperthyroidism was a risk factor for hyperuricemia with an odd ratio of 4.536 for men and 2.730 for women. CONCLUSIONS: For hyperuricemia, hyperthyroidism was an important risk factor that should not be neglected, especially for men.
Authors: H Fukui; S Taniguchi ; Y Ueta; A Yoshida; A Ohtahara; I Hisatome; C Shigemasa Journal: J Clin Endocrinol Metab Date: 2001-05 Impact factor: 5.958
Authors: R Yahyaoui; I Esteva; J J Haro-Mora; M C Almaraz; S Morcillo; G Rojo-Martínez; J Martínez; J M Gómez-Zumaquero; I González; V Hernando; F Soriguer Journal: J Clin Endocrinol Metab Date: 2008-03-18 Impact factor: 5.958