T Buttgereit1, M Maurer2. 1. Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. Thomas.Buttgereit@charite.de. 2. Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
Abstract
BACKGROUND: The classification of angioedema in daily clinical practice is often challenging. OBJECTIVES: The goal is to review the most recent classification of angioedema and to discuss the underlying pathology. MATERIALS AND METHODS: Current guidelines and research on the pathophysiology and classification of angioedema were evaluated. RESULTS: Angioedema is mast cell mediator-induced or bradykinin-mediated. Classic examples for mast cell mediator-induced angioedema are acute angioedema due to allergic reactions or acute urticaria as well as recurrent angioedema in chronic urticaria. Bradykinin-mediated angioedema forms include hereditary angioedema and angiotensin converting enzyme (ACE) inhibitor-induced angioedema. Bradykinin-mediated angioedema is less common than mast cell mediator-induced angioedema and often more severe. The diagnostic workup of angioedema patients includes a good medical history and subsequent laboratory testing. CONCLUSIONS: In most cases, mast cell mediator-induced and bradykinin-mediated forms of angioedema are readily classified clinically and/or by laboratory tests. In very rare cases, however, the cause and mediators of angioedema remain unknown.
BACKGROUND: The classification of angioedema in daily clinical practice is often challenging. OBJECTIVES: The goal is to review the most recent classification of angioedema and to discuss the underlying pathology. MATERIALS AND METHODS: Current guidelines and research on the pathophysiology and classification of angioedema were evaluated. RESULTS:Angioedema is mast cell mediator-induced or bradykinin-mediated. Classic examples for mast cell mediator-induced angioedema are acute angioedema due to allergic reactions or acute urticaria as well as recurrent angioedema in chronic urticaria. Bradykinin-mediated angioedema forms include hereditary angioedema and angiotensin converting enzyme (ACE) inhibitor-induced angioedema. Bradykinin-mediated angioedema is less common than mast cell mediator-induced angioedema and often more severe. The diagnostic workup of angioedemapatients includes a good medical history and subsequent laboratory testing. CONCLUSIONS: In most cases, mast cell mediator-induced and bradykinin-mediated forms of angioedema are readily classified clinically and/or by laboratory tests. In very rare cases, however, the cause and mediators of angioedema remain unknown.
Authors: Sengwee Toh; Marsha E Reichman; Monika Houstoun; Mary Ross Southworth; Xiao Ding; Adrian F Hernandez; Mark Levenson; Lingling Li; Carolyn McCloskey; Azadeh Shoaibi; Eileen Wu; Gwen Zornberg; Sean Hennessy Journal: Arch Intern Med Date: 2012-11-12
Authors: M Worm; G Edenharter; F Ruëff; K Scherer; C Pföhler; V Mahler; R Treudler; R Lang; K Nemat; A Koehli; B Niggemann; S Hompes Journal: Allergy Date: 2012-02-16 Impact factor: 13.146
Authors: M Maurer; K Weller; C Bindslev-Jensen; A Giménez-Arnau; P J Bousquet; J Bousquet; G W Canonica; M K Church; K V Godse; C E H Grattan; M W Greaves; M Hide; D Kalogeromitros; A P Kaplan; S S Saini; X J Zhu; T Zuberbier Journal: Allergy Date: 2010-11-17 Impact factor: 13.146
Authors: M Magerl; E Borzova; A Giménez-Arnau; C E H Grattan; F Lawlor; P Mathelier-Fusade; M Metz; A Młynek; M Maurer Journal: Allergy Date: 2009-09-30 Impact factor: 13.146
Authors: Marcus Maurer; Markus Magerl; Stephen Betschel; Werner Aberer; Ignacio J Ansotegui; Emel Aygören-Pürsün; Aleena Banerji; Noémi-Anna Bara; Isabelle Boccon-Gibod; Konrad Bork; Laurence Bouillet; Henrik Balle Boysen; Nicholas Brodszki; Paula J Busse; Anette Bygum; Teresa Caballero; Mauro Cancian; Anthony J Castaldo; Danny M Cohn; Dorottya Csuka; Henriette Farkas; Mark Gompels; Richard Gower; Anete S Grumach; Guillermo Guidos-Fogelbach; Michihiro Hide; Hye-Ryun Kang; Allen P Kaplan; Constance H Katelaris; Sorena Kiani-Alikhan; Wei-Te Lei; Richard F Lockey; Hilary Longhurst; William Lumry; Andrew MacGinnitie; Alejandro Malbran; Inmaculada Martinez Saguer; Juan José Matta Campos; Alexander Nast; Dinh Nguyen; Sandra A Nieto-Martinez; Ruby Pawankar; Jonathan Peter; Grzegorz Porebski; Nieves Prior; Avner Reshef; Marc Riedl; Bruce Ritchie; Farrukh Rafique Sheikh; William B Smith; Peter J Spaeth; Marcin Stobiecki; Elias Toubi; Lilian Agnes Varga; Karsten Weller; Andrea Zanichelli; Yuxiang Zhi; Bruce Zuraw; Timothy Craig Journal: World Allergy Organ J Date: 2022-04-07 Impact factor: 5.516