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Literature DB >> 3050526

Detection of Candida sp. mannan antigen by indirect ELISA-inhibition. In vitro crossed reactivity among mannans obtained from C. albicans A, C. albicans B, and C. tropicalis.

J Garcia-de-Lomas¹, C Morales, M A Grau, A Mir.

Abstract

We have obtained mannans from four Candida species: C. albicans A, C. albicans B and C. tropicalis; anti-mannan sera against C. albicans A, C. albicans B and C. tropicalis were obtained by immunizing rabbits subcutaneously with the respective yeast extract. The efficacy of these sera in reacting with mannans obtained from three Candida sp. has been proven by indirect ELISA-inhibition. Any of three immune sera can be used to detect mannan antigen from the three Candida sp. tested. This confirms the existence of crossed reactivity and the possibility of detecting mannan antigen in serum from patients infected by different Candida sp., although we had only one immune serum and one Candida mannan.

Entities: Chemical Species

Mesh：

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Year: 1988 PMID： 3050526 DOI： 10.1007/BF00437401

Source DB: PubMed Journal: Mycopathologia ISSN： 0301-486X Impact factor: 2.574

27 in total

1. The growth of Candida albicans in nutritive solutions given parenterally.

Authors: M F Brennan; R C O'Connell; J A Rosol; R Kundsin
Journal: Arch Surg Date: 1971-12

2. Immunodiagnosis of systemic candidiasis: mannan antigenemia detected by radioimmunoassay in experimental and human infections.

Authors: M H Weiner; M Coats-Stephen
Journal: J Infect Dis Date: 1979-12 Impact factor: 5.226

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Authors: J E Edwards; R I Lehrer; E R Stiehm; T J Fischer; L S Young
Journal: Ann Intern Med Date: 1978-07 Impact factor: 25.391

4. Fungemia in the immunocompromised host. Changing patterns, antigenemia, high mortality.

Authors: F Meunier-Carpentier; T E Kiehn; D Armstrong
Journal: Am J Med Date: 1981-09 Impact factor: 4.965

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Authors: M H Weiner; W J Yount
Journal: J Clin Invest Date: 1976-11 Impact factor: 14.808

6. Necrotic skin lesions associated with disseminated candidiasis.

Authors: T M File; O A Marina; F P Flowers
Journal: Arch Dermatol Date: 1979-02

Review 7. Candida esophagitis.

Authors: R Mathieson; S K Dutta
Journal: Dig Dis Sci Date: 1983-04 Impact factor: 3.199

Detection of Candida sp. mannan antigen by indirect ELISA-inhibition. In vitro crossed reactivity among mannans obtained from C. albicans A, C. albicans B, and C. tropicalis.

1. The growth of Candida albicans in nutritive solutions given parenterally.

2. Immunodiagnosis of systemic candidiasis: mannan antigenemia detected by radioimmunoassay in experimental and human infections.

Review 3. Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy.

4. Fungemia in the immunocompromised host. Changing patterns, antigenemia, high mortality.

5. Mannan antigenemia in the diagnosis of invasive Candida infections.

6. Necrotic skin lesions associated with disseminated candidiasis.

Review 7. Candida esophagitis.

8. Candida infections in surgical patients.

9. Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis.

10. Fever, rash, and muscle tenderness. A distinctive clinical presentation of disseminated candidiasis.

1. Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells.