Bo Yang1, Qi Wang1, Rui Wang1, Tao Xu2. 1. Department of Urology, Peking University People's Hospital, Beijing, China. 2. Department of Urology, Peking University People's Hospital, Beijing, China, xutaourology@163.com.
Abstract
BACKGROUND/AIMS: Cardiovascular complications are the most common cause of death in individuals with autosomal dominant polycystic kidney disease (ADPKD), yet there is no substantial data concerning the clinical characteristics of acute myocardial infarction (AMI) in this population. This study thus aimed to investigate AMI in persons with ADPKD. METHODS: A retrospective analysis of ADPKD patients admitted to our hospital over a 13 year period was conducted. Age and gender-matched control patients without ADPKD were also selected at a ratio of 1: 10. RESULTS: A total of 52 ADPKD and 520 non-ADPKD patients were enrolled in the present study, with those in the former group exhibiting significantly poorer kidney function. The distribution of AMI types differed significantly between these two groups. The incidence of ST-segment elevation myocardial infarction (STEMI) was higher (75.0%) and the incidence of non-ST segment elevation myocardial infarction (NSTEMI) was lower (25.0%) in the ADPKD group. At the onset of AMI, sudden cardiac death (SCD) was more common in ADPKD patients (11.5% vs. 4.6%). In terms of risk factors, the occurrence of hypertension was greater in ADPKD patients (78.8% vs. 39.6%). With regard to subsequent management, ADPKD patients had a higher prevalence of triple-branch coronary lesions (21.1% vs. 11.2%), undergoing more coronary artery bypass grafting (CABG) (7.7% vs. 5.4%) and fewer percutaneous coronary interventions (PCI) (73.1% vs. 84.6%). Overall, ADPKD patients had higher rates of mortality (13.5% vs. 6.2%). CONCLUSION: ADPKD patients with AMI suffer from more severe conditions and difficult therapies, resulting in a poorer prognosis.
BACKGROUND/AIMS: Cardiovascular complications are the most common cause of death in individuals with autosomal dominant polycystic kidney disease (ADPKD), yet there is no substantial data concerning the clinical characteristics of acute myocardial infarction (AMI) in this population. This study thus aimed to investigate AMI in persons with ADPKD. METHODS: A retrospective analysis of ADPKDpatients admitted to our hospital over a 13 year period was conducted. Age and gender-matched control patients without ADPKD were also selected at a ratio of 1: 10. RESULTS: A total of 52 ADPKD and 520 non-ADPKDpatients were enrolled in the present study, with those in the former group exhibiting significantly poorer kidney function. The distribution of AMI types differed significantly between these two groups. The incidence of ST-segment elevation myocardial infarction (STEMI) was higher (75.0%) and the incidence of non-ST segment elevation myocardial infarction (NSTEMI) was lower (25.0%) in the ADPKD group. At the onset of AMI, sudden cardiac death (SCD) was more common in ADPKDpatients (11.5% vs. 4.6%). In terms of risk factors, the occurrence of hypertension was greater in ADPKDpatients (78.8% vs. 39.6%). With regard to subsequent management, ADPKDpatients had a higher prevalence of triple-branch coronary lesions (21.1% vs. 11.2%), undergoing more coronary artery bypass grafting (CABG) (7.7% vs. 5.4%) and fewer percutaneous coronary interventions (PCI) (73.1% vs. 84.6%). Overall, ADPKDpatients had higher rates of mortality (13.5% vs. 6.2%). CONCLUSION:ADPKDpatients with AMI suffer from more severe conditions and difficult therapies, resulting in a poorer prognosis.
Authors: Vicente Pallares-Carratalá; José Manuel Valdivielso; José Luis Gorriz; David Arroyo; Luis D'Marco; Roser Torra; Patricia Tomás; María Jesús Puchades; Nayara Panizo; Jonay Pantoja; Marco Montomoli; José Luis Llisterri Journal: BMC Nephrol Date: 2021-03-25 Impact factor: 2.388
Authors: Sara S Jdiaa; Nedaa M Husainat; Razan Mansour; Mohamad A Kalot; Kerri McGreal; Fouad T Chebib; Ronald D Perrone; Alan Yu; Reem A Mustafa Journal: Kidney Int Rep Date: 2022-07-05