Mélanie Barbay1, Momar Diouf2, Martine Roussel3, Olivier Godefroy3. 1. Department of Neurology and Laboratory of Functional Neurosciences (EA 4559), Amiens University Hospital, Amiens, France, barbay.melanie@chu-amiens.fr. 2. Department of Biostatistics, Amiens University Hospital, Amiens, France. 3. Department of Neurology and Laboratory of Functional Neurosciences (EA 4559), Amiens University Hospital, Amiens, France.
Abstract
BACKGROUND/AIMS: Post-stroke neurocognitive disorders (post-stroke NCD) have been reported with a very variable prevalence. METHODS: Based on a systematic literature search, hospital-based studies published between January 1990 and September 2015 were selected when they reported the prevalence of total, mild, and major post-stroke NCD diagnosed by using specified criteria. Factors affecting prevalence were assessed using meta-regression analysis. RESULTS: Among the 7,440 references evaluated, 16 hospital-based studies were selected, corresponding to a total of 3,087 patients. The overall prevalence of total post-stroke NCD was 53.4% (95% CI: 46.9-59.8): 36.4% for mild post-stroke NCD (95% CI: 29-43.8) and 16.5% (95% CI: 12.1-20.8) for major post-stroke NCD. The overall prevalence was mainly influenced by the threshold score used for categorization (p = 0.0001) and, in the subgroup of studies using a conservative threshold (i.e., ≤7th percentile), by the recurrent stroke rate (p = 0.0005). The prevalence of major post-stroke NCD was mainly influenced by age (p = 0.003). CONCLUSION: More than half of stroke survivors experience post-stroke NCD, corresponding to mild post-stroke NCD in two-thirds of cases and major post-stroke NCD in one-third of cases. Harmonization of stroke assessment and cognitive score thresholds is urgently needed to allow more accurate estimation of post-stroke NCD prevalence, especially mild post-stroke NCD.
BACKGROUND/AIMS: Post-stroke neurocognitive disorders (post-stroke NCD) have been reported with a very variable prevalence. METHODS: Based on a systematic literature search, hospital-based studies published between January 1990 and September 2015 were selected when they reported the prevalence of total, mild, and major post-stroke NCD diagnosed by using specified criteria. Factors affecting prevalence were assessed using meta-regression analysis. RESULTS: Among the 7,440 references evaluated, 16 hospital-based studies were selected, corresponding to a total of 3,087 patients. The overall prevalence of total post-stroke NCD was 53.4% (95% CI: 46.9-59.8): 36.4% for mild post-stroke NCD (95% CI: 29-43.8) and 16.5% (95% CI: 12.1-20.8) for major post-stroke NCD. The overall prevalence was mainly influenced by the threshold score used for categorization (p = 0.0001) and, in the subgroup of studies using a conservative threshold (i.e., ≤7th percentile), by the recurrent stroke rate (p = 0.0005). The prevalence of major post-stroke NCD was mainly influenced by age (p = 0.003). CONCLUSION: More than half of stroke survivors experience post-stroke NCD, corresponding to mild post-stroke NCD in two-thirds of cases and major post-stroke NCD in one-third of cases. Harmonization of stroke assessment and cognitive score thresholds is urgently needed to allow more accurate estimation of post-stroke NCD prevalence, especially mild post-stroke NCD.
Authors: Qing Zhao; Xue Wang; Tao Wang; Adam A Dmytriw; Xiao Zhang; Kun Yang; Jichang Luo; Xuesong Bai; Nan Jiang; Bin Yang; Yan Ma; Liqun Jiao; Yunyan Xie Journal: Syst Rev Date: 2021-03-04
Authors: Nora-Ann Donnelly; Eithne Sexton; Niamh A Merriman; Kathleen E Bennett; David J Williams; Frances Horgan; Paddy Gillespie; Anne Hickey; Maev-Ann Wren Journal: Int J Environ Res Public Health Date: 2020-10-01 Impact factor: 3.390
Authors: Knut K Kolskår; Geneviève Richard; Dag Alnaes; Erlend S Dørum; Anne-Marthe Sanders; Kristine M Ulrichsen; Jennifer Monereo Sánchez; Hege Ihle-Hansen; Jan E Nordvik; Lars T Westlye Journal: Hum Brain Mapp Date: 2020-11-20 Impact factor: 5.399