Pawel Domoslawski1, Bartosz Pula2, Mateusz Olbromski2, Beata Wojtczak3, Tadeusz Lukienczuk3, Marzenna Podhorska-Okolow2, Piotr Dziegiel2,4. 1. Department of General, Gastroenterological and Endocrine Surgery, Medical University of Wroclaw, Wroclaw, Poland pawel.domoslawski@umed.wroc.pl. 2. Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland. 3. Department of General, Gastroenterological and Endocrine Surgery, Medical University of Wroclaw, Wroclaw, Poland. 4. Department of Physiotherapy, Wroclaw University School of Physical Education, Wroclaw, Poland.
Abstract
BACKGROUND/AIM: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients. RESULTS: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Cytoplasmic and nuclear MT-I/II expression correlated strongly with GD (r=0.51; p<0.0001) and NG (r=0.50; p=0.0137). Cytoplasmic MT-I/II expression was significantly higher in GD (mean IRS 9.24±2.36) than in NG (mean IRS 7.13±2.51; p=0.0006) and correlated positively with Ki-67 antigen expression (r=0.28; p=0.0165). Nuclear MT-I/II expression was elevated in GD (mean 3.53±0.65) in comparison to NG (mean 2.96±0.86; p=0.028). CONCLUSION: MT-I/II may be a potential marker of GD in the thyroid and may be potentially involved in thyrocytes' proliferation. Copyright
BACKGROUND/AIM: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients. RESULTS:MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Cytoplasmic and nuclear MT-I/II expression correlated strongly with GD (r=0.51; p<0.0001) and NG (r=0.50; p=0.0137). Cytoplasmic MT-I/II expression was significantly higher in GD (mean IRS 9.24±2.36) than in NG (mean IRS 7.13±2.51; p=0.0006) and correlated positively with Ki-67 antigen expression (r=0.28; p=0.0165). Nuclear MT-I/II expression was elevated in GD (mean 3.53±0.65) in comparison to NG (mean 2.96±0.86; p=0.028). CONCLUSION:MT-I/II may be a potential marker of GD in the thyroid and may be potentially involved in thyrocytes' proliferation. Copyright
Authors: Urszula Ciesielska; Aleksandra Piotrowska; Christopher Kobierzycki; Wojciech Pastuszewski; Marzenna Podhorska-Okolow; Piotr Dziegiel; Katarzyna Nowinska Journal: In Vivo Date: 2020 Nov-Dec Impact factor: 2.155