Literature DB >> 30503938

Antitumoral activity of quinoxaline derivatives: A systematic review.

M Montana1, F Mathias2, T Terme2, P Vanelle3.   

Abstract

Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, the majority of drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promise for the development of more efficient and safer anticancer drugs. Quinoxaline and its derivatives are becoming recognized as a novel class of chemotherapeutic agents with activity against different tumors. The present review compiles and discusses studies concerning the therapeutic potential of the anticancer activity of quinoxaline derivatives, covering articles published between July 2013 and July 2018.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Anticancer; Biological applications; Chemistry; Kinase inhibitors; Quinoxaline; SAR

Mesh：

Substances：

Year:  2018        PMID： 30503938     DOI： 10.1016/j.ejmech.2018.11.059

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  13 in total

1.  Activities of Quinoxaline, Nitroquinoxaline, and [1,2,4]Triazolo[4,3-a]quinoxaline Analogs of MMV007204 against Schistosoma mansoni.

Authors:  Stefan L Debbert; Mikaela J Hintz; Christian J Bell; Kenya R Earl; Grant E Forsythe; Cécile Häberli; Jennifer Keiser
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

2.  Synthesis of Morpholine-, Piperidine-, and N-Substituted Piperazine-Coupled 2-(Benzimidazol-2-yl)-3-arylquinoxalines as Novel Potent Antitumor Agents.

Authors:  Vakhid A Mamedov; Nataliya A Zhukova; Alexandra D Voloshina; Victor V Syakaev; Tat'yana N Beschastnova; Anna P Lyubina; Syumbelya K Amerhanova; Aida I Samigullina; Aidar T Gubaidullin; Daina N Buzyurova; Il Dar Kh Rizvanov; Oleg G Sinyashin
Journal:  ACS Pharmacol Transl Sci       Date:  2022-09-01

Review 3.  Anticancer activity of monoterpenes: a systematic review.

Authors:  Bruno I M Silva; Erika A Nascimento; Cleber J Silva; Teresinha G Silva; Jaciana S Aguiar
Journal:  Mol Biol Rep       Date:  2021-07-24       Impact factor: 2.316

4.  Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives.

Authors:  Fabián Amaya-García; Michael Caldera; Anna Koren; Stefan Kubicek; Jörg Menche; Miriam M Unterlass
Journal:  ChemSusChem       Date:  2021-03-26       Impact factor: 8.928

5.  Quinoxaline Derivatives as Antiviral Agents: A Systematic Review.

Authors:  Marc Montana; Vincent Montero; Omar Khoumeri; Patrice Vanelle
Journal:  Molecules       Date:  2020-06-16       Impact factor: 4.411

Review 6.  Recent advances in the transition-metal-free synthesis of quinoxalines.

Authors:  Biplob Borah; L Raju Chowhan
Journal:  RSC Adv       Date:  2021-11-19       Impact factor: 4.036

7.  New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies.

Authors:  Mohammed M Alanazi; Hazem Elkady; Nawaf A Alsaif; Ahmad J Obaidullah; Hamad M Alkahtani; Manal M Alanazi; Madhawi A Alharbi; Ibrahim H Eissa; Mohammed A Dahab
Journal:  RSC Adv       Date:  2021-10-12       Impact factor: 4.036

Review 8.  Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles.

Authors:  Biplob Borah; L Raju Chowhan
Journal:  RSC Adv       Date:  2022-05-11       Impact factor: 4.036

9.  Synthesis and Characterization of Some New Quinoxalin-2(1H)one and 2-Methyl-3H-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SAR, Molecular Docking, and ADMET Analyses.

Authors:  Nahed N E El-Sayed; Taghreed M Al-Otaibi; Mona Alonazi; Vijay H Masand; Assem Barakat; Zainab M Almarhoon; Abir Ben Bacha
Journal:  Molecules       Date:  2021-05-23       Impact factor: 4.927

10.  Understanding the aqueous chemistry of quinoline and the diazanaphthalenes: insight from DFT study.

Authors:  Obieze C Enudi; Hitler Louis; Moses M Edim; John A Agwupuye; Francis O Ekpen; Emmanuel A Bisong; Patrick M Utsu
Journal:  Heliyon       Date:  2021-07-10
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