Javier Santabárbara1, Darren M Lipnicki2, Beatriz Villagrasa3, Elena Lobo1, Raul Lopez-Anton4. 1. Departamento de Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain. 2. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Randwick, Australia. 3. Servicio de Psiquiatría, Hospital Clínico Universitario, Avda. San Juan Bosco 15, 50009 Zaragoza, Spain. 4. Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain; Departamento de Psicología y Sociología, Universidad de Zaragoza, C/Doctor Cerrada 1-5, 50009 Zaragoza, Spain. Electronic address: rlanton@unizar.es.
Abstract
OBJECTIVES: Anxiety is postulated to be modifiable risk factor for dementia. Our primary aim was to conduct a meta-analysis of community-based cohort studies that investigated the association between anxiety and dementia. DESIGN: We identified relevant, high-quality papers published up to January 2018 by searching PubMed and Web of Science. Prospective cohort studies reporting relative risks (RRs) for the association between anxiety and dementia, adjusted at least for age, were considered eligible. Study-specific RRs were combined using a random-effects model. RESULTS: Six prospective cohorts (reported in 5 studies), with a total of 10,394 participants, were included in the meta-analysis. The pooled RR of 1.29 (95% CI: 1.01-1.66) indicated a significant association between anxiety and dementia. CONCLUSION: Anxiety significantly increases the risk of dementia. However, further research is needed to determine the extent to which anxiety is a cause of dementia rather than a prodrome or marker.
OBJECTIVES:Anxiety is postulated to be modifiable risk factor for dementia. Our primary aim was to conduct a meta-analysis of community-based cohort studies that investigated the association between anxiety and dementia. DESIGN: We identified relevant, high-quality papers published up to January 2018 by searching PubMed and Web of Science. Prospective cohort studies reporting relative risks (RRs) for the association between anxiety and dementia, adjusted at least for age, were considered eligible. Study-specific RRs were combined using a random-effects model. RESULTS: Six prospective cohorts (reported in 5 studies), with a total of 10,394 participants, were included in the meta-analysis. The pooled RR of 1.29 (95% CI: 1.01-1.66) indicated a significant association between anxiety and dementia. CONCLUSION:Anxiety significantly increases the risk of dementia. However, further research is needed to determine the extent to which anxiety is a cause of dementia rather than a prodrome or marker.
Authors: Javier Santabárbara; Darren M Lipnicki; Beatriz Olaya; Beatriz Villagrasa; Patricia Gracia-García; Juan Bueno-Notivol; Antonio Lobo; Raúl López-Antón Journal: J Clin Med Date: 2020-05-06 Impact factor: 4.241
Authors: Javier Santabárbara; Juan Bueno-Notivol; Darren M Lipnicki; Concepción de la Cámara; Raúl López-Antón; Antonio Lobo; Patricia Gracia-García Journal: Int J Environ Res Public Health Date: 2021-02-12 Impact factor: 3.390