Helena Marcos-Pasero1, Elena Aguilar-Aguilar2, Rocío de la Iglesia3, Isabel Espinosa-Salinas4, Mónica Gómez-Patiño5, Gonzalo Colmenarejo6, Ana Ramírez de Molina7, Guillermo Reglero8, Viviana Loria-Kohen9. 1. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: helena.marcos@imdea.org. 2. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: elena.aguilar@imdea.org. 3. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: rocio.delaiglesia@imdea.org. 4. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: mariaisabel.espinosa@imdea.org. 5. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: monica.gomez@imdea.org. 6. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: gonzalo.colmenarejo@imdea.org. 7. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: ana.ramirez@imdea.org. 8. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain; Department of Production and Characterization of Novel Foods, Institute of Food Science Research (CIAL) CEI UAM+CSIC, Calle Nicolás Cabrera, 9, 28049 Madrid, Spain. Electronic address: guillermo.reglero@imdea.org. 9. IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain. Electronic address: viviana.loria@imdea.org.
Abstract
BACKGROUND & AIMS: Calcium and dairy products have multiple health benefits. The objective of this work was to evaluate the association between calcium/dairy intake, blood pressure, the BDNF-AS rs925946 polymorphism and nutritional status in a group of schoolchildren. METHODS: As part of the GENYAL study to childhood obesity prevention, 221 children belonging to different areas of the Community of Madrid were enrolled. Anthropometric and dietary data were collected, and children were genotyped according to the rs925946 polymorphism. Adjusted logistic and linear models were used to describe the data. RESULTS: A significantly lower consumption of calcium in overweight versus normal weight children was observed (811.0 ± 174.1; 859.0 ± 195.9; 954.0 ± 223.1 mg; for obesity, overweight and normal weight, respectively, p = 0.010). Moreover, an inverse association between blood pressures and calcium intake was detected (β = -0.006 (-0.011, -3e-4)), p = 0.040. The number of dairy servings/day showed a protective effect against overweight (OR = 0.48 (0.29, 0.75), p = 0.001). Finally, common homozygous children (GG) showed an inverse association between the calcium intake and the BMI (β = -0.003 (-0.006, -0.001), p = 0.004), which was not observed in children carrying the T allele (β = -1.3e-4 (-0.0022, 0.0024), p = 0.93). CONCLUSION: Calcium and dairy were strongly associated with the nutritional status and blood pressure. The identification of differential effects of calcium/dairy consumption on the nutritional status according to genetics may contribute to the personalization of future nutritional advice. TRIAL REGISTRATION: This study is registered at www.clinicaltrials.govNCT03419520.
BACKGROUND & AIMS:Calcium and dairy products have multiple health benefits. The objective of this work was to evaluate the association between calcium/dairy intake, blood pressure, the BDNF-ASrs925946 polymorphism and nutritional status in a group of schoolchildren. METHODS: As part of the GENYAL study to childhood obesity prevention, 221 children belonging to different areas of the Community of Madrid were enrolled. Anthropometric and dietary data were collected, and children were genotyped according to the rs925946 polymorphism. Adjusted logistic and linear models were used to describe the data. RESULTS: A significantly lower consumption of calcium in overweight versus normal weight children was observed (811.0 ± 174.1; 859.0 ± 195.9; 954.0 ± 223.1 mg; for obesity, overweight and normal weight, respectively, p = 0.010). Moreover, an inverse association between blood pressures and calcium intake was detected (β = -0.006 (-0.011, -3e-4)), p = 0.040. The number of dairy servings/day showed a protective effect against overweight (OR = 0.48 (0.29, 0.75), p = 0.001). Finally, common homozygous children (GG) showed an inverse association between the calcium intake and the BMI (β = -0.003 (-0.006, -0.001), p = 0.004), which was not observed in children carrying the T allele (β = -1.3e-4 (-0.0022, 0.0024), p = 0.93). CONCLUSION:Calcium and dairy were strongly associated with the nutritional status and blood pressure. The identification of differential effects of calcium/dairy consumption on the nutritional status according to genetics may contribute to the personalization of future nutritional advice. TRIAL REGISTRATION: This study is registered at www.clinicaltrials.govNCT03419520.