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Literature DB >> 30500598

Systematic evaluation of the population-level effects of alternative treatment strategies on the basic reproduction number.

Dmitry Gromov¹, Ingo Bulla², Ethan O Romero-Severson³.

Abstract

An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R0, is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of different treatment strategies on the basic reproduction number. All our results are valid for sufficiently small values of the control. However, in many cases it is possible to extend this analysis to larger values of the control as was illustrated by examples.

Entities: Chemical Disease Gene Species

Keywords: Basic reproduction number; Compartmental epidemic model; Disease control; Next generation matrix; Treatment

Mesh：

Year: 2018 PMID： 30500598 PMCID： PMC7005901 DOI： 10.1016/j.jtbi.2018.11.029

Source DB: PubMed Journal: J Theor Biol ISSN： 0022-5193 Impact factor: 2.691

18 in total

1. What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic?

Authors: Eline L Korenromp; Mondastri K Sudaryo; Sake J de Vlas; Ronald H Gray; Nelson K Sewankambo; David Serwadda; Maria J Wawer; J Dik F Habbema
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2. Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission.

Authors: P van den Driessche; James Watmough
Journal: Math Biosci Date: 2002 Nov-Dec Impact factor: 2.144

3. To treat or not to treat: the case of tuberculosis.

Authors: C Castillo-Chavez; Z Feng
Journal: J Math Biol Date: 1997-06 Impact factor: 2.259

Review 4. Forecasting the future of HIV epidemics: the impact of antiretroviral therapies & imperfect vaccines.

Authors: S Blower; E J Schwartz; J Mills
Journal: AIDS Rev Date: 2003 Apr-Jun Impact factor: 2.500

Review 5. Perspectives on the basic reproductive ratio.

Authors: J M Heffernan; R J Smith; L M Wahl
Journal: J R Soc Interface Date: 2005-09-22 Impact factor: 4.118

Review 6. Syphilis.

Authors: Patrick French
Journal: BMJ Date: 2007-01-20

1. Within-Host Phenotypic Evolution and the Population-Level Control of Chronic Viral Infections by Treatment and Prophylaxis.

Authors: Dmitry Gromov; Ethan O Romero-Severson
Journal: Mathematics (Basel) Date: 2020-09-04

1 in total

Systematic evaluation of the population-level effects of alternative treatment strategies on the basic reproduction number.

1. What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic?

2. Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission.

3. To treat or not to treat: the case of tuberculosis.

Review 4. Forecasting the future of HIV epidemics: the impact of antiretroviral therapies & imperfect vaccines.

Review 5. Perspectives on the basic reproductive ratio.

Review 6. Syphilis.

7. Mathematical analysis of the transmission dynamics of HIV/TB coinfection in the presence of treatment.

8. Virologic characteristics of subclinical and symptomatic genital herpes infections.

9. The epidemiological impact of antiretroviral use predicted by mathematical models: a review.

10. Strong influence of behavioral dynamics on the ability of testing and treating HIV to stop transmission.

1. Within-Host Phenotypic Evolution and the Population-Level Control of Chronic Viral Infections by Treatment and Prophylaxis.