| Literature DB >> 30500566 |
Fernando Galvão1, Kamila Castro Grokoski2, Bruno Batista da Silva3, Marcelo Lazzaron Lamers4, Ionara Rodrigues Siqueira5.
Abstract
Aging is a risk factor for several illnesses, such as Alzheimer's Disease and various cancers. However, an inverse correlation between malignancies and Alzheimer's Disease has been suggested. This review addressed the potential role of non-amyloidogenic and amyloidogenic pathways of amyloid precursor protein processing as a relevant biochemical mechanism to clarify this association. Amyloidogenic and non-amyloidogenic pathways have been related to Alzheimer's Disease and certain malignancies, respectively. Several known molecules involved in APP processing, including its regulation and final products, were summarized. Among them some candidate mechanisms emerged, such as extracellular-regulated kinase (Erk) and protein kinase C (PKC). Therefore, the imbalance of APP processing may be involved with the negative correlation between cancer and Alzheimer Disease.Entities:
Keywords: Aging; Alzheimer disease; Amyloid precursor protein; Amyloidogenic pathway; Cancer; Non- amyloidogenic pathway
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Year: 2018 PMID： 30500566 DOI： 10.1016/j.arr.2018.11.007
Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895