| Literature DB >> 3050008 |
P F Watson1, M E Rose, S L Kelly.
Abstract
Nine mutants of Saccharomyces cerevisiae which are resistant to ketoconazole, have been isolated and characterized. In each case the mutation is nuclear in origin and allelic to a previously described mutation, erg3, which gives rise to a block in the delta 5-6 desaturation step of ergosterol biosynthesis. The significance of this second site mutation to the point of inhibitory action of ketoconazole, that is the P-450-mediated C-14 demethylation of lanosterol, is discussed.Entities:
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Year: 1988 PMID： 3050008 DOI： 10.1080/02681218880000231
Source DB: PubMed Journal: J Med Vet Mycol ISSN： 0268-1218