Kim Oren Gradel1, Pedro Póvoa1,2,3, Pernille Just Vinholt4, Bjarne Magnussen1, Court Pedersen5, Thøger Gorm Jensen6, Hans Jørn Kolmos6, Annmarie Touborg Lassen7. 1. Center for Clinical Epidemiology, Odense University Hospital, and Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Kløvervænget 30, Entrance 216, ground floor, 5000 Odense C, Denmark. 2. The Polyvalent Intensive Care Unit, Hospital deSão Francisco Xavier, CHLO, Estrada do Forte do Alto do Duque, 1449-005 Lisbon, Portugal. 3. NOVA Medical School, CEDOC, New University of Lisbon, Campo dos Mártires da Pátria, 1169-056 Lisbon, Portugal. 4. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Sdr Boulevard 29, entrance 40, 5000 Odense C, Denmark. 5. Department of Infectious Diseases, Odense University Hospital, Sdr Boulevard 29, entrance 20, 5000 Odense C, Denmark. 6. Department of Clinical Microbiology, Odense University Hospital, JB Winsløws Vej 21, 2nd floor, 5000 Odense C, Denmark. 7. Department of Emergency Medicine, Odense University Hospital, Kløvervænget 25, entrance 63-65, 5000 Odense C, Denmark.
Abstract
AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia. PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups. RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.
AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia. PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremiapatients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups. RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremiapatients.
Entities:
Keywords:
C-reactive protein; bacteremia; community-acquisition; daily mean level trajectories; plasma albumin
Authors: O S Garvik; P Póvoa; B Magnussen; P J Vinholt; C Pedersen; T G Jensen; H J Kolmos; A T Lassen; K O Gradel Journal: Epidemiol Infect Date: 2020-02-26 Impact factor: 2.451