Himadri Singh1, Samuel Joshua Pragasam1, Vijayalakshmi Venkatesan1.
Abstract
BACKGROUND: Metabolic syndrome is a cluster of medical conditions that synergistically increase the risk of heart diseases and diabetes. The current treatment strategy for metabolic syndrome focuses on treating its individual components. A highly effective agent for metabolic syndrome has yet to be developed. To develop a target for metabolic syndrome, the mechanism encompassing different organs - nervous system, pancreas, skeletal muscle, liver and adipose tissue - needs to be understood. Many animal models have been developed to understand the pathophysiology of metabolic syndrome. Promising molecular targets have emerged while characterizing these animals. Modulating these targets is expected to treat some components of metabolic syndrome.
OBJECTIVE: To discuss the emerging molecular targets in an animal model of metabolic syndrome.
METHODS: A literature search was performed for the retrieval of relevant articles.
CONCLUSION: Multiple genes/pathways that play important role in the development of Metabolic Syndrome are discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: Metabolic syndrome is a cluster of medical conditions that synergistically increase the risk of heart diseases and diabetes. The current treatment strategy for metabolic syndrome focuses on treating its individual components. A highly effective agent for metabolic syndrome has yet to be developed. To develop a target for metabolic syndrome, the mechanism encompassing different organs - nervous system, pancreas, skeletal muscle, liver and adipose tissue - needs to be understood. Many animal models have been developed to understand the pathophysiology of metabolic syndrome. Promising molecular targets have emerged while characterizing these animals. Modulating these targets is expected to treat some components of metabolic syndrome.
OBJECTIVE: To discuss the emerging molecular targets in an animal model of metabolic syndrome.
METHODS: A literature search was performed for the retrieval of relevant articles.
CONCLUSION: Multiple genes/pathways that play important role in the development of Metabolic Syndrome are discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities:
Keywords:
NCDs; Obesity; animal models; diabetes; inflammation; metabolic syndrome.
Mesh：
Substances：
Year: 2019
PMID： 30499422 DOI： 10.2174/1871530319666181130142642
Source DB: PubMed Journal: Endocr Metab Immune Disord Drug Targets ISSN： 1871-5303 Impact factor: 2.895