Literature DB >> 30498909

Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials.

Jordy Schol1, Daisuke Sakai2.   

Abstract

Low back pain is the primary cause of disability and is highly associated with progression of intervertebral disc degeneration. Current treatment options are limited and fail to address the origin of the problem. New advancements in cellular therapies might offer novel and potent strategies for low back pain patients. In this review, we summarize and discuss the contemporary status of in-human trials investigating cellular transplantation for treatment of low back pain. We aim to highlight current trends, shortcomings, and hurdles for effective clinical trials and consecutive commercialization.

Entities:  

Keywords:  Cell therapy; Clinical trials; Degeneration; Intervertebral disc; Regenerative medicine

Mesh：

Year:  2018        PMID： 30498909     DOI： 10.1007/s00264-018-4223-1

Source DB:  PubMed          Journal:  Int Orthop        ISSN： 0341-2695            Impact factor:   3.075


  60 in total

1.  Cost-benefit and cost-effectiveness analysis of a disability prevention model for back pain management: a six year follow up study.

Authors:  P Loisel; J Lemaire; S Poitras; M-J Durand; F Champagne; S Stock; B Diallo; C Tremblay
Journal:  Occup Environ Med       Date:  2002-12       Impact factor: 4.402

2.  Spinal-fusion surgery - the case for restraint.

Authors:  Richard A Deyo; Alf Nachemson; Sohail K Mirza
Journal:  N Engl J Med       Date:  2004-02-12       Impact factor: 91.245

3.  2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group.

Authors:  P Fritzell; O Hägg; P Wessberg; A Nordwall
Journal:  Spine (Phila Pa 1976)       Date:  2001-12-01       Impact factor: 3.468

4.  Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc.

Authors:  Hans Jörg Meisel; Vilma Siodla; Timothy Ganey; Yvonne Minkus; William C Hutton; Olivera J Alasevic
Journal:  Biomol Eng       Date:  2006-07-21

5.  Clinical experience in cell-based therapeutics: intervention and outcome.

Authors:  Hans Joerg Meisel; Timothy Ganey; William C Hutton; Jeanette Libera; Yvonne Minkus; Olivera Alasevic
Journal:  Eur Spine J       Date:  2006-07-19       Impact factor: 3.134

Review 6.  Lumbar disc disorders and low-back pain: socioeconomic factors and consequences.

Authors:  Jeffrey N Katz
Journal:  J Bone Joint Surg Am       Date:  2006-04       Impact factor: 5.284

7.  Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc.

Authors:  F Mwale; P Roughley; J Antoniou
Journal:  Eur Cell Mater       Date:  2004-12-15       Impact factor: 3.942

8.  Disc chondrocyte transplantation in a canine model: a treatment for degenerated or damaged intervertebral disc.

Authors:  Timothy Ganey; Jeanette Libera; Verena Moos; Olivera Alasevic; Karl-Gerd Fritsch; Hans Joerg Meisel; William C Hutton
Journal:  Spine (Phila Pa 1976)       Date:  2003-12-01       Impact factor: 3.468

9.  Expenditures and health status among adults with back and neck problems.

Authors:  Brook I Martin; Richard A Deyo; Sohail K Mirza; Judith A Turner; Bryan A Comstock; William Hollingworth; Sean D Sullivan
Journal:  JAMA       Date:  2008-02-13       Impact factor: 56.272

10.  Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs.

Authors:  Scott M W Haufe; Anthony R Mork
Journal:  Stem Cells Dev       Date:  2006-02       Impact factor: 3.272
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  22 in total

1.  Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells.

Authors:  Kosuke Sako; Daisuke Sakai; Yoshihiko Nakamura; Jordy Schol; Erika Matsushita; Takayuki Warita; Natsumi Horikita; Masato Sato; Masahiko Watanabe
Journal:  Int J Mol Sci       Date:  2021-04-29       Impact factor: 5.923

2.  Intradiscal Injection of Autologous Discogenic Cells in Patients with Discectomy: A Prospective Clinical Study of Its Safety and Feasibility.

Authors:  Anwu Xuan; Dike Ruan; Chaofeng Wang; Qing He; Deli Wang; Lisheng Hou; Chao Zhang; Chao Li; Wei Ji; Tianyong Wen; Cheng Xu; Zhenbiao Zhu
Journal:  Stem Cells Transl Med       Date:  2022-05-27       Impact factor: 7.655

3.  Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review.

Authors:  Tibo Nico Emmie Volleman; Jordy Schol; Kosuke Morita; Daisuke Sakai; Masahiko Watanabe
Journal:  Neurospine       Date:  2020-03-31

4.  Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro.

Authors:  Tadashi Nukaga; Daisuke Sakai; Jordy Schol; Kaori Suyama; Tomoko Nakai; Akihiko Hiyama; Masahiko Watanabe
Journal:  Spine Surg Relat Res       Date:  2019-08-16

5.  Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2.

Authors:  Chao Sun; Weiren Lan; Bin Li; Rui Zuo; Hui Xing; Minghan Liu; Jie Li; Yuan Yao; Junlong Wu; Yu Tang; Huan Liu; Yue Zhou
Journal:  Stem Cell Res Ther       Date:  2019-11-28       Impact factor: 6.832

6.  Patient-specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs.

Authors:  Ward Shalash; Sonia R Ahrens; Liudmila A Bardonova; Vadim A Byvaltsev; Morgan B Giers
Journal:  JOR Spine       Date:  2021-11-22

7.  The Cellular Composition of Bovine Coccygeal Intervertebral Discs: A Comprehensive Single-Cell RNAseq Analysis.

Authors:  Martina Calió; Benjamin Gantenbein; Marcel Egli; Lucy Poveda; Fabian Ille
Journal:  Int J Mol Sci       Date:  2021-05-06       Impact factor: 5.923

8.  Crosslinker concentration controls TGFβ-3 release and annulus fibrosus cell apoptosis in genipin-crosslinked fibrin hydrogels.

Authors:  C J Panebianco; T J DiStefano; B Mui; W W Hom; J C Iatridis
Journal:  Eur Cell Mater       Date:  2020-05-12       Impact factor: 3.942

9.  Balancing biological and biomechanical performance in intervertebral disc repair: a systematic review of injectable cell delivery biomaterials.

Authors:  C J Panebianco; J H Meyers; J Gansau; W W Hom; J C Iatridis
Journal:  Eur Cell Mater       Date:  2020-11-18       Impact factor: 3.942

10.  Comparison of total disc arthroplasty and fusion in treatment of lumbar disc disease: A cohort study protocol.

Authors:  Yi Wang; Yunting Bai; Haoguang Ma; Shaolei Wang
Journal:  Medicine (Baltimore)       Date:  2020-08-28       Impact factor: 1.817
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