Lu Liu1,2, Fei Zhou1,3, Xiaoxia Zhang4, Shuchen Liu1,3, Liyuan Liu1,3, Yujuan Xiang1,3, Mingming Guo1,3, Lixiang Yu1,3, Fei Wang1,3, Zhongbing Ma1,3, Liang Li1,3, Dezong Gao1,3, Qiang Zhang1,3, Qinye Fu1,3, Zhigang Yu1,3. 1. Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong, China. 2. Department of Breast Surgery, Qingdao Municipal Hospital Group, Qingdao, Shandong, China. 3. Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, Shandong, China. 4. Department of Thyroid and Breast Surgery, Linyi People's Hospital, Linyi, Shandong, China.
Abstract
BACKGROUND: Granulomatous lobular mastitis (GLM) is a rare chronic inflammatory condition of the breast. The purpose of this study was to describe antituberculous treatment of GLM and the long-term follow-up outcome. METHODS: This retrospective study included 22 patients who had been histopathologically diagnosed with GLM at the Second Hospital of Shandong University from January 2011 to March 2015. Clinical characteristics, ultrasonography and mammography findings, laboratory tests, treatment regimens, follow-up information, and recurrences were recorded. RESULTS: All patients were female with a median age of 29 (range 23-44) years. The most common symptom was a breast mass with or without pain. Large irregular hypoechoic masses could be found in the breast ultrasounds of 13 patients. All patients received triple antituberculous therapy. During a median follow-up period of 40 months, 3 patients were lost to follow-up; of the remaining 19 patients, 18 achieved clinical complete remission and no recurrences were observed. CONCLUSION: GLM is an unusual benign breast condition that mimics breast carcinoma in its clinical and imaging presentation. Antituberculous therapy seems to be an effective alternative option in the treatment of GLM.
BACKGROUND: Granulomatous lobular mastitis (GLM) is a rare chronic inflammatory condition of the breast. The purpose of this study was to describe antituberculous treatment of GLM and the long-term follow-up outcome. METHODS: This retrospective study included 22 patients who had been histopathologically diagnosed with GLM at the Second Hospital of Shandong University from January 2011 to March 2015. Clinical characteristics, ultrasonography and mammography findings, laboratory tests, treatment regimens, follow-up information, and recurrences were recorded. RESULTS: All patients were female with a median age of 29 (range 23-44) years. The most common symptom was a breast mass with or without pain. Large irregular hypoechoic masses could be found in the breast ultrasounds of 13 patients. All patients received triple antituberculous therapy. During a median follow-up period of 40 months, 3 patients were lost to follow-up; of the remaining 19 patients, 18 achieved clinical complete remission and no recurrences were observed. CONCLUSION: GLM is an unusual benign breast condition that mimics breast carcinoma in its clinical and imaging presentation. Antituberculous therapy seems to be an effective alternative option in the treatment of GLM.
Authors: Eric C H Lai; Wing Cheong Chan; Tony K F Ma; Alice P Y Tang; Cycles S P Poon; Heng Tat Leong Journal: Breast J Date: 2005 Nov-Dec Impact factor: 2.431
Authors: Marcia E Bouton; Lisa M Winton; Sonal G Gandhi; Lakshmi Jayaram; Prahladbhai N Patel; Patrick J O' Neill; Ian K Komenaka Journal: Int J Surg Case Rep Date: 2015-03-04