Confirmation of early Kaposi's sarcoma by polyclonal antibody to type IV collagen.

By the use of polyclonal antibody to type IV collagen that binds to epitope(s) retained in routinely processed tissues, we have confirmed the presence of early Kaposi's sarcoma in skin lesions that were not diagnostic on histologic examination. This reagent is of considerable use, particularly in cases of rapidly developing Kaposi's sarcoma with acquired immunodeficiency syndrome in which histologic features may not be fully developed.