| Literature DB >> 3049216 |
J H Hoofnagle1, M Peters, K D Mullen, D B Jones, V Rustgi, A Di Bisceglie, C Hallahan, Y Park, C Meschievitz, E A Jones.
Abstract
Forty-five patients with chronic hepatitis B were entered into a randomized controlled trial of recombinant human alpha-interferon therapy. All patients had hepatitis B surface antigen in serum for at least 1 yr and had stable serum levels of both hepatitis B virus deoxyribonucleic acid and hepatitis B e antigen. During the 4-mo period of therapy, 10 of 31 (32%) treated patients and only 1 of 14 (7%) control patients became negative for serum hepatitis B virus deoxyribonucleic acid and deoxyribonucleic acid polymerase. All 10 patients who became negative for serum hepatitis B virus deoxyribonucleic acid subsequently had a marked improvement in serum aminotransferase activities and lost hepatitis B e antigen from serum, and 9 of them had improvement in liver histology. Comparison of responders to nonresponders indicated that female sex and a high initial level of serum aspartate aminotransferase correlated best with response to interferon therapy. These findings indicate that a 4-mo course of recombinant alpha-interferon can induce a remission in disease in approximately one-third of patients with chronic hepatitis B.Entities:
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Year: 1988 PMID： 3049216 DOI： 10.1016/0016-5085(88)90367-8
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682