Literature DB >> 3049067

Streptokinase--biochemistry and clinical application.

K N Reddy1.   

Abstract

Plasminogen activation to plasmin is due to enzymatic cleavage of a single peptide bond in the zymogen molecule. Streptokinase is not an enzyme and its activation of plasminogen is indirect. Streptokinase forms stoichiometric complexes with plasmin and plasminogen and these complexes activate plasminogen to plasmin. Streptokinase is species selective in its action.

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Year:  1988        PMID： 3049067     DOI： 10.1159/000469149

Source DB:  PubMed          Journal:  Enzyme        ISSN： 0013-9432


  4 in total

1.  A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator.

Authors:  G L Reed; A K Houng; L Liu; B Parhami-Seren; L H Matsueda; S Wang; L Hedstrom
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

2.  Effects of streptokinase on the development of rat cerebral cortical cells in vitro.

Authors:  V N Nikandrov; O N Zhuk
Journal:  Neurosci Behav Physiol       Date:  2006-10

3.  Cloning, expression, sequence analysis, and characterization of streptokinases secreted by porcine and equine isolates of Streptococcus equisimilis.

Authors:  A R Caballero; R Lottenberg; K H Johnston
Journal:  Infect Immun       Date:  1999-12       Impact factor: 3.441

Review 4.  Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination.

Authors:  Sarbani Bhattacharya; Victoria A Ploplis; Francis J Castellino
Journal:  J Biomed Biotechnol       Date:  2012-10-14
  4 in total

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