| Literature DB >> 30489589 |
Marja Ter Meer1, Ross Dillion, Signe Maria Nielsen, Raoul Walther, Rikke L Meyer, Willeke F Daamen, Lambertus P van den Heuvel, J Adam van der Vliet, Roger M L M Lomme, Yvonne L Hoogeveen, Leo J Schultze Kool, Jeremy E Schaffer, Alexander N Zelikin.
Abstract
Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.Entities:
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Year: 2019 PMID： 30489589 DOI： 10.1039/c8cc08737g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222