Literature DB >> 30488201

Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles.

L A Sharafutdinova1, A M Fedorova2, S A Bashkatov2, K N Sinel'nikov2, V V Valiullin3.   

Abstract

We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganization of layers, and detachment of sperm cells from the basement membrane. Immunohistochemical analysis revealed reduced proliferative activity and differentiation potential of epithelial cells, which was confirmed by changes in the expression of Ki-67 and c-kit markers. Our data attest to unfavorable effects of titanium dioxide nanoparticles on the structural and functional characteristics of the reproductive system in male rats leading to spermatogenesis disturbances.

Entities:  

Keywords:  nanoparticles; spermatogenesis; titanium dioxide; toxicity

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Substances：

Year:  2018        PMID： 30488201     DOI： 10.1007/s10517-018-4332-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin.

Authors:  Mohamed M A Hussein; Emad Gad; Mona M Ahmed; Ahmed H Arisha; Hasnaa F Mahdy; Ayman Abdel-Aziz Swelum; Hammed A Tukur; Islam M Saadeldin
Journal:  Environ Sci Pollut Res Int       Date:  2019-08-07       Impact factor: 4.223

2.  Inhibition of testosterone synthesis induced by oral TiO2 NPs is associated with ROS-MAPK(ERK1/2)-StAR signaling pathway in SD rat.

Authors:  Shanji Liu; Yizhou Tang; Bolu Chen; Yu Zhao; Zoraida P Aguilar; Xueying Tao; Hengyi Xu
Journal:  Toxicol Res (Camb)       Date:  2021-08-09       Impact factor: 2.680

3.  Histopathological and Biochemical Comparative Study of Copper Oxide Nanoparticles and Copper Sulphate Toxicity in Male Albino Mice Reproductive System.

Authors:  Manal M S Al-Musawi; Hanady Al-Shmgani; Genan A Al-Bairuty
Journal:  Int J Biomater       Date:  2022-05-16

Review 4.  Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles-A Systematic Review.

Authors:  Dora Rolo; Ricardo Assunção; Célia Ventura; Paula Alvito; Lídia Gonçalves; Carla Martins; Ana Bettencourt; Peter Jordan; Nádia Vital; Joana Pereira; Fátima Pinto; Paulo Matos; Maria João Silva; Henriqueta Louro
Journal:  Nanomaterials (Basel)       Date:  2022-09-21       Impact factor: 5.719
  4 in total

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