| Literature DB >> 30488196 |
A S Sotnichenko1, R Z Nakokhov2, E A Gubareva2, E V Kuevda2, I S Gumenyuk2.
Abstract
Based on the data of morphological analysis, we performed histological evaluation of rat tissue reaction to subcutaneous implantation of decellularized matrices of intrathoracic organs and tissues. Cell composition of the inflammatory infiltrate was analyzed, and the dynamics of macrophage and T and B lymphocyte content was assessed on days 7 and 14 of the experiment. It was found that the reaction to implantation depended not only on the quality of decellularization and efficiency of removal of antigen molecules, but also on the original histological structure and quality of preimplantation processing of the transplant.Entities:
Keywords: biological scaffolds; decellularization; rats; tissue engineering
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Year: 2018 PMID： 30488196 DOI： 10.1007/s10517-018-4334-0
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804