Literature DB >> 30488195

Reception of Sex Steroid Hormones in Thyroid Papillary Cancer Tissue and Relationship with Expression and Content of Transcription Factors Brn-3α and TRIM16.

L V Spirina1,2, S Yu Chizhevskaya3, I V Kondakova3, E L Choinzonov3,4.   

Abstract

We studied reception of sex steroid hormones in the tissues of thyroid papillary cancer and benign tumor. Enhanced expression of AR and ERβ mRNA reflected malignant tumor growth. Nuclear factors Brn-3α and TRIM16 modulating expression of steroid hormones play an important role in the development of thyroid tumors. It was found that the level of TRIM16 mRNA is associated with the expression of ERβ, which seems to be mediated by its antiestrogen effect.

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Keywords:  AR; Brn-3α; ER; TRIM16; thyroid cancer

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Year:  2018        PMID： 30488195     DOI： 10.1007/s10517-018-4322-4

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  1 in total

1.  The Association of the BRAF-V600E Mutation with the Expression of the Molecular Markers in the Primary Tumor and Metastatic Tissue in Papillary Thyroid Cancer.

Authors:  Liudmila V Spirina; Svetlana Yu Chizhevskaya; Irina V Kovaleva; Irina V Kondakova
Journal:  Asian Pac J Cancer Prev       Date:  2021-07-01
  1 in total

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