Einar Andreas Sivertsen1,2, Kari Bente Foss Haug3, Eirik Klami Kristianslund2,4, Anne-Marie Siebke Trøseid3, Jari Parkkari5, Terho Lehtimäki6, Nina Mononen6, Kati Pasanen5,7, Roald Bahr2. 1. Department of Surgery, Diakonhjemmet Hospital, Oslo, Norway. 2. Oslo Sports Trauma Research Center, Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway. 3. Department of Medical Biochemistry, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 4. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. 5. Tampere Research Center of Sports Medicine, UKK Institute, Tampere, Finland. 6. Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 7. Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
Abstract
BACKGROUND: Several single-nucleotide variants (SNVs) in collagen genes have been reported as predisposing factors for anterior cruciate ligament (ACL) tears. However, the evidence is conflicting and does not support a clear association between genetic variants and risk of ACL ruptures. PURPOSE: To assess the association of previously identified candidate SNVs in genes encoding for collagen and the risk of ACL injury in a population of elite female athletes from high-risk team sports. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A total of 851 female Norwegian and Finnish elite athletes from team sports were included from 2007 to 2011. ACL injuries acquired before inclusion in the cohort were registered by interview. The participants were followed prospectively through 2015 to record new complete ACL injuries. Six selected SNVs were genotyped ( COL1A1: rs1800012, rs1107946; COL3A1: rs1800255; COL5A1: rs12722, rs13946; COL12A1: rs970547). RESULTS: No associations were found between ACL rupture and the SNVs tested. CONCLUSION: The study does not support a role of the 6 selected SNVs in genes encoding for collagen proteins as risk factors for ACL injury. CLINICAL RELEVANCE: Genetic profiling to identify athletes at high risk for ACL rupture is not yet feasible.
BACKGROUND: Several single-nucleotide variants (SNVs) in collagen genes have been reported as predisposing factors for anterior cruciate ligament (ACL) tears. However, the evidence is conflicting and does not support a clear association between genetic variants and risk of ACL ruptures. PURPOSE: To assess the association of previously identified candidate SNVs in genes encoding for collagen and the risk of ACL injury in a population of elite female athletes from high-risk team sports. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A total of 851 female Norwegian and Finnish elite athletes from team sports were included from 2007 to 2011. ACL injuries acquired before inclusion in the cohort were registered by interview. The participants were followed prospectively through 2015 to record new complete ACL injuries. Six selected SNVs were genotyped ( COL1A1: rs1800012, rs1107946; COL3A1: rs1800255; COL5A1: rs12722, rs13946; COL12A1: rs970547). RESULTS: No associations were found between ACL rupture and the SNVs tested. CONCLUSION: The study does not support a role of the 6 selected SNVs in genes encoding for collagen proteins as risk factors for ACL injury. CLINICAL RELEVANCE: Genetic profiling to identify athletes at high risk for ACL rupture is not yet feasible.
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