Literature DB >> 3048482

A case of accidental cyclosporin overdose with pharmacokinetic analysis.

H U Krüger1, U Bross-Bach, B Proksch, H Schmidt, R Dopfer, G Ehninger.   

Abstract

In a case of oral overdose of cyclosporin we measured plasma concentrations by radioimmunoassay and high pressure liquid chromatography. We observed unchanged pharmacokinetic parameters after the overdose indicating normal renal and hepatic function. Laboratory findings showed no renal or hepatic damage. As toxic symptoms, only emesis and a short, mild drowsiness were noted.

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Year:  1988        PMID: 3048482

Source DB:  PubMed          Journal:  Bone Marrow Transplant        ISSN: 0268-3369            Impact factor:   5.483


  3 in total

Review 1.  Acute cyclosporin overdose. A review of present clinical experience.

Authors:  F Arellano; C Monka; P F Krupp
Journal:  Drug Saf       Date:  1991 Jul-Aug       Impact factor: 5.606

Review 2.  Cyclosporin clinical pharmacokinetics.

Authors:  A Fahr
Journal:  Clin Pharmacokinet       Date:  1993-06       Impact factor: 6.447

3.  Hospitalized poisonings after renal transplantation in the United States.

Authors:  Kevin C Abbott; Rebecca A Viola; Lawrence Y Agodoa
Journal:  BMC Nephrol       Date:  2002-11-26       Impact factor: 2.388

  3 in total

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