Obsessive-compulsive disorder: is there a frontal lobe dysfunction?

Obsessive-compulsive disorder has recently been found to be associated with various biochemical markers; this has revived interest in its biological basis. Most of the work to date has concentrated on the neurotransmitters involved. In this presentation, evidence from electrophysiological, neuropsychological, scan, lesion, and psychosurgical studies are integrated to focus on a possible frontal dysfunction in this disorder.