Renato Matta Ramos1,2, Marion Burland3,4, Jefferson Braga Silva5,6, Lauren Marquardt Burman7, Marco Smiderle Gelain8, Leticia Manoel Debom7, Jean Michel Bec3, Mohsen Alirezai9, Carlos Oscar Uebel7, Jean Valmier4,9. 1. Plastic Surgery Division of São Lucas Hospital of Pontificia, Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. renatomatta82@hotmail.com. 2. Bliss Plastic Surgery, Private Clinic, Libertadores Street. 125. Postal Code: Lima 14, San Isidro Lima, Peru. renatomatta82@hotmail.com. 3. Biolux Institute, Phare de la méditerranée, 34250, Palavas Les Flots, Montpellier, France. 4. Inserm U1051, University of Montpellier, Montpellier, France. 5. Hand and Reconstructive Microsurgery Division of São Lucas Hospital of Pontificia, Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. 6. School of Medicine, PUCRS University, Montpellier Cedex 5, Montpellier, France. 7. Plastic Surgery Division of São Lucas Hospital of Pontificia, Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. 8. Universidade Federal de Ciências da Saúde de Porto Alegre, San Isidro, Lima, Peru. 9. Inserm U1051., INM, Hôpital St Eloi, University Hospital Center of Montpellier, 80 rue Augustin Fliche, 34091, Montpellier Cedex 5, France.
Abstract
BACKGROUND: Photobiomodulation is widely studied for its potential benefits in the wound healing process. Numerous scientific studies have highlighted its effect on various phases of wound repair, but clinical validations are few. This comparative trial aims to evaluate the influence of photobiomodulation on the post-abdominoplasty healing process. METHODS:Seventeen Caucasian women (aged 18-55) who underwent an abdominoplasty were enrolled in this double-blinded, controlled clinical trial. The postoperative scars were divided into two areas; the right side of the scars was treated with ten sessions of photobiomodulation (consisting in three types of wavelengths). The other part of the scars was used as control and did not receive any additional treatment. Clinical assessments of both parts of the scars were scheduled at 1, 6 and 12 months postoperative. RESULTS: Within six months following surgery, significantly improved quality of the scars on the treated side compared with the untreated side was reported by patients and experienced professionals according to Vancouver Scar Scale, Patient and Observer Scar Assessment Scale (p < 0.05) and standardized photographs (p < 0.05). At 1 year of follow-up, patients observed no differences between the treated and untreated sides of the scars. This suggests that photobiomodulation appears to play an early role in the wound healing process, accelerating the first stages of cicatrization. CONCLUSION: This study statistically validates the positive impact of photobiomodulation treatment on the first stages of the postoperative healing process. Carried out on Caucasians participants only, this study should, however, be performed on a more heterogeneous population to definitively confirm these effects on an international population. CLINICAL TRIAL REGISTRY: Registro Brasileiro de ensaios clínicos: http://www.ensaiosclinicos.gov.br , Trial RBR-49PK78. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
RCT Entities:
BACKGROUND: Photobiomodulation is widely studied for its potential benefits in the wound healing process. Numerous scientific studies have highlighted its effect on various phases of wound repair, but clinical validations are few. This comparative trial aims to evaluate the influence of photobiomodulation on the post-abdominoplasty healing process. METHODS: Seventeen Caucasian women (aged 18-55) who underwent an abdominoplasty were enrolled in this double-blinded, controlled clinical trial. The postoperative scars were divided into two areas; the right side of the scars was treated with ten sessions of photobiomodulation (consisting in three types of wavelengths). The other part of the scars was used as control and did not receive any additional treatment. Clinical assessments of both parts of the scars were scheduled at 1, 6 and 12 months postoperative. RESULTS: Within six months following surgery, significantly improved quality of the scars on the treated side compared with the untreated side was reported by patients and experienced professionals according to Vancouver Scar Scale, Patient and Observer Scar Assessment Scale (p < 0.05) and standardized photographs (p < 0.05). At 1 year of follow-up, patients observed no differences between the treated and untreated sides of the scars. This suggests that photobiomodulation appears to play an early role in the wound healing process, accelerating the first stages of cicatrization. CONCLUSION: This study statistically validates the positive impact of photobiomodulation treatment on the first stages of the postoperative healing process. Carried out on Caucasians participants only, this study should, however, be performed on a more heterogeneous population to definitively confirm these effects on an international population. CLINICAL TRIAL REGISTRY: Registro Brasileiro de ensaios clínicos: http://www.ensaiosclinicos.gov.br , Trial RBR-49PK78. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Authors: Jefferson André Pires; Erick Frank Bragato; Marcos Momolli; Marina Bertoni Guerra; Leonel Manea Neves; Meire Augusto de Oliveira Bruscagnin; Anna Carolina Ratto Tempestini Horliana; Kristianne Porta Santos Fernandes; Sandra Kalil Bussadori; Raquel Agnelli Mesquita Ferrari Journal: PLoS One Date: 2022-02-15 Impact factor: 3.240