Background: In Burkina Faso, serogroup A meningococcal (NmA) conjugate vaccine (PsA-TT, MenAfriVac) was introduced through a mass campaign in children and adults in December 2010. Similar to a serological survey in 2011, we followed population-level antibody persistence for 5 years after the campaign and estimated time of return to previously-published pre-vaccination levels. Methods: We conducted 2 cross-sectional surveys in 2013 and early 2016, including representative samples (N = 600) of the general population of Bobo-Dioulasso, Burkina Faso. Serum bactericidal antibody titers (rabbit complement) were measured against NmA reference strain F8236 (SBA-ref), NmA strain 3125 (SBA-3125), and NmA-specific immunoglobulin G (IgG) concentrations. Results: During the 2016 survey, in different age groups between 6 and 29 years, the relative changes in geometric means compared to 2011 values were greater among younger age groups. They were between -87% and -43% for SBA-ref; -99% and -78% for SBA-3125; and -89% and -63% for IgG. In linear extrapolation of age-specific geometric means from 2013 to 2016, among children aged 1-4 years at the time of the PsA-TT campaign, a return to pre-vaccination levels should be expected after 12, 8, and 6 years, respectively, according to SBA-ref, SBA-3125, and IgG. Among older individuals, complete return to baseline is expected at the earliest after 11 years (SBA-ref and SBA-3125) or 9 years (IgG). Conclusions: Based on SBA-3125, a booster campaign after 8 years would be required to sustain direct immune protection for children aged 1-4 years during the PsA-TT campaign. Antibodies persisted longer in older age groups.
Background: In Burkina Faso, serogroup A meningococcal (NmA) conjugate vaccine (PsA-TT, MenAfriVac) was introduced through a mass campaign in children and adults in December 2010. Similar to a serological survey in 2011, we followed population-level antibody persistence for 5 years after the campaign and estimated time of return to previously-published pre-vaccination levels. Methods: We conducted 2 cross-sectional surveys in 2013 and early 2016, including representative samples (N = 600) of the general population of Bobo-Dioulasso, Burkina Faso. Serum bactericidal antibody titers (rabbit complement) were measured against NmA reference strain F8236 (SBA-ref), NmA strain 3125 (SBA-3125), and NmA-specific immunoglobulin G (IgG) concentrations. Results: During the 2016 survey, in different age groups between 6 and 29 years, the relative changes in geometric means compared to 2011 values were greater among younger age groups. They were between -87% and -43% for SBA-ref; -99% and -78% for SBA-3125; and -89% and -63% for IgG. In linear extrapolation of age-specific geometric means from 2013 to 2016, among children aged 1-4 years at the time of the PsA-TT campaign, a return to pre-vaccination levels should be expected after 12, 8, and 6 years, respectively, according to SBA-ref, SBA-3125, and IgG. Among older individuals, complete return to baseline is expected at the earliest after 11 years (SBA-ref and SBA-3125) or 9 years (IgG). Conclusions: Based on SBA-3125, a booster campaign after 8 years would be required to sustain direct immune protection for children aged 1-4 years during the PsA-TT campaign. Antibodies persisted longer in older age groups.
Authors: Jaspreet Toor; Susy Echeverria-Londono; Xiang Li; Kaja Abbas; Emily D Carter; Hannah E Clapham; Andrew Clark; Margaret J de Villiers; Kirsten Eilertson; Matthew Ferrari; Ivane Gamkrelidze; Timothy B Hallett; Wes R Hinsley; Daniel Hogan; John H Huber; Michael L Jackson; Kevin Jean; Mark Jit; Andromachi Karachaliou; Petra Klepac; Alicia Kraay; Justin Lessler; Xi Li; Benjamin A Lopman; Tewodaj Mengistu; C Jessica E Metcalf; Sean M Moore; Shevanthi Nayagam; Timos Papadopoulos; T Alex Perkins; Allison Portnoy; Homie Razavi; Devin Razavi-Shearer; Stephen Resch; Colin Sanderson; Steven Sweet; Yvonne Tam; Hira Tanvir; Quan Tran Minh; Caroline L Trotter; Shaun A Truelove; Emilia Vynnycky; Neff Walker; Amy Winter; Kim Woodruff; Neil M Ferguson; Katy Am Gaythorpe Journal: Elife Date: 2021-07-13 Impact factor: 8.140
Authors: Katy Am Gaythorpe; Kaja Abbas; John Huber; Andromachi Karachaliou; Niket Thakkar; Matthew Ferrari; Michael L Jackson; Kevin McCarthy; T Alex Perkins; Caroline Trotter; Mark Jit; Kim Woodruff; Xiang Li; Susy Echeverria-Londono Journal: Elife Date: 2021-06-24 Impact factor: 8.140
Authors: Ryan T Novak; Olivier Ronveaux; André F Bita; Honoré Flavien Aké; Fernanda C Lessa; Xin Wang; Ado M Bwaka; LeAnne M Fox Journal: J Infect Dis Date: 2019-10-31 Impact factor: 7.759