| Literature DB >> 30480107 |
Sunghye Kim1, Xiaoyan I Leng2, Stephen B Kritchevsky3,4.
Abstract
BACKGROUND: Lower muscle and higher fat mass are characteristics of older adults; their physical function is also characterized by slower gait speed and weaker strength. However, the association between specific body composition and physical function is unclear.Entities:
Keywords: 4 m walk speed; BMI; Body composition; Body percent (%) fat; Percent appendicular lean mass; Physical function; SPPB
Year: 2017 PMID: 30480107 PMCID: PMC6177091 DOI: 10.1093/geroni/igx008
Source DB: PubMed Journal: Innov Aging ISSN: 2399-5300
Summary of Participants Included in This Report Per Study (N = 1,821)
| Study name and acronym | Condition(s) |
| Female (%) | Whites (%) | Mean age, years ( |
|---|---|---|---|---|---|
| Combined | 1,821 | 1,183 (65) | 1,460 (80) | 69.8 (6.5) | |
| Arthritis, Diet, and Activity Promotion Trial (ADAPT) | Knee osteoarthritis | 265 | 187 (71) | 203 (77) | 68.4 (6.0) |
| Cooperative Lifestyle Intervention Program (CLIP) | Evidence of myocardial infarction (MI), percutaneous coronary transluminal intervention (PCTI), chronic stable angina, cardiovascular surgery, or an ATP III diagnosis of metabolic syndrome | 287 | 192 (67) | 235 (82) | 67.1 (4.8) |
| Diet, Exercise and Metabolism in Older Women (DEMO) | Obese women | 46 | 46 (100) | 37 (80) | 64.9 (2.6) |
| Leg blood flow, sarcopenia and physical function (FLOW) | 15 with heart failure vs 15 healthy | 23 | 11 (48) | Unknown | 68.8 (6.8) |
| Database of determinants of physical function in healthy older persons (HEALTHY) | Healthy—free of chronic diseases | 60 | 37 (62) | 57 (95) | 69.8 (7.4) |
| Intensive Diet and Exercise for Arthritis (IDEA) | Knee osteoarthritis | 342 | 239 (70) | 283 (83) | 67.4 (5.4) |
| Lifestyle Interventions and Independence for Elders-Pilot (LIFE-P) | Elevated risk of disability | 269 | 194 (72) | 215 (80) | 76.7 (4.1) |
| Optimizing Body Composition in Older Adults (OPTIMA) | At risk for disability and with indications for weight loss | 88 | 40 (45) | 78 (89) | 70.6 (3.6) |
| Impact of a Physical Activity Intervention on Physical Function and Quality of Life in Aging Candidates for Renal Transplantation (PART) | Renal transplant candidates | 24 | 7 (29) | 15 (63) | 65.1 (4.6) |
| Pharmacological Intervention in the Elderly (PIE) | Heart failure with normal ejection fraction | 48 | 39 (81) | 42 (88) | 71.2 (7.2) |
| Resistance Training to Increase Muscle POWER in Older Adults (POWER) | Moderate self-reported disability | 45 | 34 (76) | 40 (89) | 75.3 (5.7) |
| Vascular Stiffness and Pulmonary Congestion (PREDICT) | History of diabetes, hypertension, or prior coronary artery disease | 109 | 62 (57) | 87 (80) | 72.7 (7.5) |
| ACE Inhibition and Novel Cardiovascular Risk Factors (TRAIN) | High cardiovascular risk profile | 215 | 95 (44) | 168 (78) | 68.9 (6.2) |
Body Composition and Physical Function of Participants Per Study
| Study | BMI, kg/m2 ( | % body fat ( | %ALM ( | 4-m walk speed, m/s ( | Chair-rise, seconds ( | Grip strength, kg ( | SPPB score, 0–12 ( | PAT-D ( |
|---|---|---|---|---|---|---|---|---|
| Combined | 31.3 (5.3) | 37.1 (7.9) | 25.8 (4.1) | 1.0 (0.2) | 15.4 (6) | 30.2 (11) | 9.6 (2) | 1.5 (0.5) |
| ADAPT | 33.1 (5.0) | 1.9 (0.6) | ||||||
| CLIP | 32.8 (3.9) | 1.1 (0.2) | 14.7 (4) | 9.9 (2) | 1.4 (0.4) | |||
| DEMO | 33.8 (4.1) | 43.9 (3.5) | 22.6 (1.2) | 1.2 (0.2) | 13.3 (3) | 30.6 (7) | 10.7 (1) | 1.2 (0.3) |
| FLOW | 26.9 (4.2) | 1.2 (0.3) | 12.3 (2) | 35.9 (12) | 10.9 (1) | 1.4 (0.7) | ||
| HEALTHY | 25.9 (4.9) | 31.5 (8.5) | 28.3 (4.4) | 1.2 (0.2) | 11.3 (3) | 34.2 (12) | 11.2 (1) | 1.1 (0.2) |
| IDEA | 33.5 (3.9) | 39.8 (6.7) | 24.3 (3.5) | 1.0 (0.2) | 12.4 (4) | 28.6 (10) | 10.8 (1) | 1.7 (0.5) |
| LIFE-P | 30.1 (6.3) | 37.7 (7.3) | 24.9 (3.6) | 0.8 (0.2) | 19.8 (9) | 24.3 (9) | 7.6 (1) | |
| OPTIMA | 32.7 (5.4) | 36.7 (7.5) | 26.7 (3.7) | 1.0 (0.2) | 17.7 (5) | 33.4 (10) | 9.0 (1) | 1.2 (0.2) |
| PART | 30.8 (5.5) | 0.9 (0.2) | 14.8 (3) | 34.3 (10) | 9.1 (2) | 1.3 (0.4) | ||
| PIE | 29.6 (4.8) | 38.1 (7.8) | 25.6 (4.0) | 1.2 (0.2) | 15.3 (4) | 28.4 (9) | 9.7 (2) | 1.9 (0.6) |
| POWER | 30.3 (5.8) | 38.2 (6.2) | 25.0 (3.1) | 1.0 (0.3) | 18.7 (8) | 9.1 (2) | 1.9 (0.5) | |
| PREDICT | 28.9 (5.1) | 1.1 (0.2) | 14.3 (3) | 29.9 (12) | 9.9 (2) | 1.5 (0.5) | ||
| TRAIN | 27.8 (4.6) | 33.3 (8.2) | 28.4 (4.3) | 1.2 (0.2) | 14.4 (4) | 37.6 (12) | 10.2 (2) | 1.4 (0.5) |
Figure 1.Regression Coefficient of each body composition for physical function assessments. 4-m walk = 4-m walk speed; Chair Rise = Repeated chair rise time; Grip = Hand grip strength; SPPB = Short Physical Performance Battery score; PAT-D = The Pepper Assessment Tool for Disability. Each bubble denotes each with the area of the bubble represents the size of the study. 1 = ADAPT, 2 = CLIP, 3 = DEMO, 4 = FLOW, 5 = HEALTHY, 6 = IDEA, 7 = LIFE-P, 8 = OPTIMA, 9 = PART, 10 = PIE, 11 = POWER, 12 = PREDICT, 13 = TRAIN.