Jason E Lang1,2,3, H Timothy Bunnell4, Md Jobayer Hossain4, Tim Wysocki5, John J Lima6, Terri H Finkel7, Leonard Bacharier8, Amanda Dempsey9, Lisa Sarzynski10, Matthew Test11, Christopher B Forrest12. 1. Nemours Children's Hospital, Nemours Children's Health System, Orlando, Florida; jason.lang@duke.org. 2. Divisions of Allergy and Immunology and. 3. Pulmonary Medicine, School of Medicine, Duke University and Duke Children's Hospital and Health Center, Durham, North Carolina. 4. Department of Biomedical Research, Nemours Alfred I. DuPont Hospital for Children, Wilmington, Delaware. 5. Centers for Health Care Delivery Science and. 6. Pharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, Florida. 7. Nemours Children's Hospital, Nemours Children's Health System, Orlando, Florida. 8. Department of Pediatrics, Washington University, St Louis, Missouri. 9. Department of Pediatrics, School of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado. 10. Section of Pulmonary Medicine, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio. 11. Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington; and. 12. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Abstract
OBJECTIVES: Adult obesity is linked to asthma cases and is estimated to lead to 250 000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not been developed for children. We sought to describe the relationship between overweight and obesity and incident asthma in childhood and quantify AR statistics in the United States for overweight and obesity on pediatric asthma. METHODS: The PEDSnet clinical data research network was used to conduct a retrospective cohort study (January 2009-December 2015) to compare asthma incidence among overweight and/or obese versus healthy weight 2- to 17-year-old children. Asthma incidence was defined as ≥2 encounters with a diagnosis of asthma and ≥1 asthma controller prescription. Stricter diagnostic criteria involved confirmation by spirometry. We used multivariable Poisson regression analyses to estimate incident asthma rates and risk ratios and accepted formulas for ARs. RESULTS: Data from 507 496 children and 19 581 972 encounters were included. The mean participant observation period was 4 years. The adjusted risk for incident asthma was increased among children who were overweight (relative risk [RR]: 1.17; 95% confidence interval [CI]: 1.10-1.25) and obese (RR: 1.26; 95% CI: 1.18-1.34). The adjusted risk for spirometry-confirmed asthma was increased among children with obesity (RR: 1.29; 95% CI: 1.16-1.42). An estimated 23% to 27% of new asthma cases in children with obesity is directly attributable to obesity. In the absence of overweight and obesity, 10% of all cases of asthma would be avoided. CONCLUSIONS: Obesity is a major preventable risk factor for pediatric asthma.
OBJECTIVES: Adult obesity is linked to asthma cases and is estimated to lead to 250 000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not been developed for children. We sought to describe the relationship between overweight and obesity and incident asthma in childhood and quantify AR statistics in the United States for overweight and obesity on pediatric asthma. METHODS: The PEDSnet clinical data research network was used to conduct a retrospective cohort study (January 2009-December 2015) to compare asthma incidence among overweight and/or obese versus healthy weight 2- to 17-year-old children. Asthma incidence was defined as ≥2 encounters with a diagnosis of asthma and ≥1 asthma controller prescription. Stricter diagnostic criteria involved confirmation by spirometry. We used multivariable Poisson regression analyses to estimate incident asthma rates and risk ratios and accepted formulas for ARs. RESULTS: Data from 507 496 children and 19 581 972 encounters were included. The mean participant observation period was 4 years. The adjusted risk for incident asthma was increased among children who were overweight (relative risk [RR]: 1.17; 95% confidence interval [CI]: 1.10-1.25) and obese (RR: 1.26; 95% CI: 1.18-1.34). The adjusted risk for spirometry-confirmed asthma was increased among children with obesity (RR: 1.29; 95% CI: 1.16-1.42). An estimated 23% to 27% of new asthma cases in children with obesity is directly attributable to obesity. In the absence of overweight and obesity, 10% of all cases of asthma would be avoided. CONCLUSIONS:Obesity is a major preventable risk factor for pediatric asthma.
Authors: Chun-Han Lo; Hamed Khalili; Paul Lochhead; Mingyang Song; Emily W Lopes; Kristin E Burke; James M Richter; Andrew T Chan; Ashwin N Ananthakrishnan Journal: Aliment Pharmacol Ther Date: 2020-12-05 Impact factor: 8.171
Authors: Brian P O'Sullivan; Laura James; Joseph M Majure; Scott Bickel; Ly-Thao Phan; Monica Serrano Gonzalez; Heather Staples; Jade Tam-Williams; Jason Lang; Jessica Snowden Journal: Pediatr Pulmonol Date: 2020-12-08
Authors: Laura Jeschke; Clarisa Guillermina Santamaria; Nicole Meyer; Ana Claudia Zenclussen; Julia Bartley; Anne Schumacher Journal: Int J Mol Sci Date: 2021-05-20 Impact factor: 5.923
Authors: Florence T Bourgeois; Alba Gutiérrez-Sacristán; Mark S Keller; Molei Liu; Chuan Hong; Clara-Lea Bonzel; Amelia L M Tan; Bruce J Aronow; Martin Boeker; John Booth; Jaime Cruz Rojo; Batsal Devkota; Noelia García Barrio; Nils Gehlenborg; Alon Geva; David A Hanauer; Meghan R Hutch; Richard W Issitt; Jeffrey G Klann; Yuan Luo; Kenneth D Mandl; Chengsheng Mao; Bertrand Moal; Karyn L Moshal; Shawn N Murphy; Antoine Neuraz; Kee Yuan Ngiam; Gilbert S Omenn; Lav P Patel; Miguel Pedrera Jiménez; Neil J Sebire; Pablo Serrano Balazote; Arnaud Serret-Larmande; Andrew M South; Anastasia Spiridou; Deanne M Taylor; Patric Tippmann; Shyam Visweswaran; Griffin M Weber; Isaac S Kohane; Tianxi Cai; Paul Avillach Journal: JAMA Netw Open Date: 2021-06-01