Literature DB >> 30476527

The Control of Neuronal Calcium Homeostasis by SNAP-25 and its Impact on Neurotransmitter Release.

Davide Pozzi1, Irene Corradini2, Michela Matteoli3.   

Abstract

The process of neurotransmitter release is central to the control of cell-to-cell communication in brain. SNAP-25 is a component of the SNARE complex, which, together with syntaxin-1 and synaptobrevin, mediates synaptic vesicle fusion with the plasma membrane. The genetic ablation of the protein or its proteolytic cleavage by botulinum neurotoxins results in a complete block of synaptic transmission. In the last years, several evidences have indicated that SNAP-25 also plays additional modulatory roles in neurotransmission through the control of voltage-gated calcium channels and presynaptic calcium ion concentration. Consistently, reduced levels of the protein affect presynaptic calcium homeostasis and result in pathologically enhanced glutamate exocytosis. The SNAP-25-dependent alterations of synaptic calcium dynamics may have direct impact on the development of neuropsychiatric disorders where the Snap-25 gene has been found to be involved.
Copyright © 2018. Published by Elsevier Ltd.

Entities:  

Keywords:  GABA; SNAP-25; calcium channels; glutamate; synaptic vesicle fusion

Year:  2018        PMID： 30476527     DOI： 10.1016/j.neuroscience.2018.11.009

Source DB:  PubMed          Journal:  Neuroscience        ISSN： 0306-4522            Impact factor:   3.590


  7 in total

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3.  Post-mortem Characterisation of a Case With an ACTG1 Variant, Agenesis of the Corpus Callosum and Neuronal Heterotopia.

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Journal:  Front Physiol       Date:  2019-05-24       Impact factor: 4.566

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Review 5.  RNA processing in neurological tissue: development, aging and disease.

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6.  The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.

Authors:  S Keihani; V Kluever; S Mandad; V Bansal; R Rahman; E Fritsch; L Caldi Gomes; A Gärtner; S Kügler; H Urlaub; J D Wren; S Bonn; S O Rizzoli; E F Fornasiero
Journal:  Sci Adv       Date:  2019-12-18       Impact factor: 14.136

7.  Synaptosomal-Associated Protein 25 Gene Polymorphisms Affect Treatment Efficiency of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder: An fNIRS Study.

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  7 in total

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