| Literature DB >> 30474499 |
Wimonchat Tangamornsuksan1,2, Ornrat Lohitnavy1,2,3, Rosarin Sruamsiri2,4, Nathorn Chaiyakunapruk2,4,5,6,7, C Norman Scholfield1,2, Brad Reisfeld1,8, Manupat Lohitnavy1,2,3.
Abstract
To reconcile and unify available results regarding paraquat exposure and Parkinson's disease (PD), we conducted a systematic review and meta-analysis to provide a quantitative estimate of the risk of PD associated with paraquat exposure. Six scientific databases including PubMed, Cochrane libraries, EMBASE, Scopus, ISI Web of Knowledge, and TOXLINE were systematically searched. The overall odds ratios (ORs) with corresponding 95% CIs were calculated using a random-effects model. Of 7,309 articles identified, 13 case control studies with 3,231 patients and 4,901 controls were included into our analysis. Whereas, one prospective cohort studies was included into our systematic review. A subsequent meta-analysis showed an association between PD and paraquat exposure (odds ratio = 1.64 (95% CI: 1.27-2.13; I2 = 24.8%). There is a statistically significant association between paraquat exposure and PD. Thus, future studies regarding paraquat and Parkinson's disease are warranted.Entities:
Keywords: Paraquat; Parkinson’s disease; systematic review and meta-analysis
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Year: 2018 PMID： 30474499 DOI： 10.1080/19338244.2018.1492894
Source DB: PubMed Journal: Arch Environ Occup Health ISSN： 1933-8244 Impact factor: 1.663