Literature DB >> 30473428

Lactate: A Metabolic Driver in the Tumour Landscape.

Luigi Ippolito1, Andrea Morandi1, Elisa Giannoni1, Paola Chiarugi2.   

Abstract

The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  mitochondria; tumour metabolism; tumour microenvironment; tumour–stroma interplay

Mesh：

Substances：

Year:  2018        PMID： 30473428     DOI： 10.1016/j.tibs.2018.10.011

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  73 in total

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Review 9.  How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression.

Authors:  Line O Elingaard-Larsen; Michala G Rolver; Ester E Sørensen; Stine F Pedersen
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Journal:  Neuropsychiatr Dis Treat       Date:  2021-06-21       Impact factor: 2.570
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