Yidan Guo1, Jingli Gao2, Pengpeng Ye3, Aijun Xing2, Yuntao Wu2, Shouling Wu4, Yang Luo5. 1. Department of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing 10038, China. 2. Department of Intensive Medicine, Kailuan General Hospital, Hebei United University, Tangshan 063000, China. 3. Division of Injury Prevention and Mental Health, The National Center for Chronic and Non-communicable Disease Control and Prevention, Beijing 100050, China. 4. Department of Intensive Medicine, Kailuan General Hospital, Hebei United University, Tangshan 063000, China. Electronic address: drwusl@163.com. 5. Department of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing 10038, China. Electronic address: luoyang96@163.com.
Abstract
OBJECTIVES: To compare clinical epidemiological features of atrial fibrillation (AF) in chronic kidney disease (CKD) and non-CKD populations. METHODS: This study included 88,312 adults aged ≥45 years old from the KAILUAN study. AF was ascertained with a 12-lead electrocardiogram. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 and/or proteinuria. Participants were categorized into non-CKD (eGFR > 60 mL/min/1.73 m2 without proteinuria, n = 66,725) and CKD (n = 21,578) groups. We evaluated the prevalence of AF in both groups, evaluated risk factors for AF using multivariable-adjusted logistic regression analysis. RESULTS: The prevalence of AF among non-CKD and CKD participants was 0.26% and 1.00%, respectively. Multivariable-adjusted analysis showed that older age (odds ratio [OR]: 1.08, 95% confidence interval [CI]: 1.07-1.10, P < 0.001), smoking (OR: 1.23, 95% CI: 1.07-1.57, P = 0.017), hypertension (OR: 2.14, 95% CI: 1.44-3.17, P < 0.001), diabetes (OR: 1.79, 95% CI: 1.10-2.89, P < 0.001), and larger waist circumference (OR: 1.03, 95% CI: 1.01-1.04, P < 0.001) were significantly associated with AF in the non-CKD group. In the CKD group, older age, smoking, larger waist circumference, reduced eGFR (OR: 0.97, 95% CI: 0.95-0.99, P < 0.001), proteinuria (OR: 2.01, 95% CI: 1.09-3.74, P < 0.001) and raised serum C-reactive protein (1.01, 1.00-1.03, P < 0.001) were significantly associated with AF. CONCLUSIONS: The prevalence of AF in Chinese adults with CKD is higher than that among those without CKD. Risk factors for AF in non-CKD population were not the same compared with those in CKD population, kidney function and inflammatory markers were associated with the prevalence of AF.
OBJECTIVES: To compare clinical epidemiological features of atrial fibrillation (AF) in chronic kidney disease (CKD) and non-CKD populations. METHODS: This study included 88,312 adults aged ≥45 years old from the KAILUAN study. AF was ascertained with a 12-lead electrocardiogram. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 and/or proteinuria. Participants were categorized into non-CKD (eGFR > 60 mL/min/1.73 m2 without proteinuria, n = 66,725) and CKD (n = 21,578) groups. We evaluated the prevalence of AF in both groups, evaluated risk factors for AF using multivariable-adjusted logistic regression analysis. RESULTS: The prevalence of AF among non-CKD and CKD participants was 0.26% and 1.00%, respectively. Multivariable-adjusted analysis showed that older age (odds ratio [OR]: 1.08, 95% confidence interval [CI]: 1.07-1.10, P < 0.001), smoking (OR: 1.23, 95% CI: 1.07-1.57, P = 0.017), hypertension (OR: 2.14, 95% CI: 1.44-3.17, P < 0.001), diabetes (OR: 1.79, 95% CI: 1.10-2.89, P < 0.001), and larger waist circumference (OR: 1.03, 95% CI: 1.01-1.04, P < 0.001) were significantly associated with AF in the non-CKD group. In the CKD group, older age, smoking, larger waist circumference, reduced eGFR (OR: 0.97, 95% CI: 0.95-0.99, P < 0.001), proteinuria (OR: 2.01, 95% CI: 1.09-3.74, P < 0.001) and raised serum C-reactive protein (1.01, 1.00-1.03, P < 0.001) were significantly associated with AF. CONCLUSIONS: The prevalence of AF in Chinese adults with CKD is higher than that among those without CKD. Risk factors for AF in non-CKD population were not the same compared with those in CKD population, kidney function and inflammatory markers were associated with the prevalence of AF.