| Literature DB >> 30473188 |
Elsa Brunet-Ratnasingham1, Mathieu Dubé2, Daniel E Kaufmann3.
Abstract
Immunometabolism is important to T cell dysfunction in chronic infections. A recent publication in The Journal of Clinical Investigation (2018;128:5083-5094) [1] shows reduced mitochondrial fitness in regulatory CD4+ T cells (Tregs) of patients with HIV and failed immune restoration on antiretroviral therapy (ART). This defect can be reversed by IL-15, revealing a new immunotherapy target for regulatory T cell restoration.Entities:
Keywords: HIV; antiretroviral therapy (ART); immune dysfunction; immunological nonresponders; mitochondrial metabolism; regulatory T cells
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Year: 2018 PMID： 30473188 DOI： 10.1016/j.molmed.2018.11.001
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951