| Literature DB >> 30472954 |
O M Antipova1,2, E G Zavyalova3,2, A V Golovin2,4,5, G V Pavlova2,5,6,7, A M Kopylov3,2, R V Reshetnikov2,4,5,6.
Abstract
Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common "alphabet" of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 amino acids. Chemical modification of nucleotides enlarges the potential of DNA/RNA aptamers. This review describes the latest achievements in a variety of approaches to aptamers selection with an extended genetic alphabet.Mesh：
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Year: 2018 PMID： 30472954 DOI： 10.1134/S0006297918100024
Source DB: PubMed Journal: Biochemistry (Mosc) ISSN： 0006-2979 Impact factor: 2.487