| Literature DB >> 30472478 |
Francisco Cunha da Rosa1, Renan Buque Pardinho2, Mauber Eduardo Schultz Moreira3, Luiz Gustavo Teixeira de Souza2, Érico Marlon de Moraes Flores2, Sergio Roberto Mortari4, Valderi Luiz Dressler5.
Abstract
In this work, we investigated the stability of arsenic trioxide (ATO) used in leukemia treatment, encapsulated with nanoliposome, with the aid of ultrasound treatment. Stability studies of As species were followed by liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS), allowing for the detection of the conversion of low amounts of As(III) to As(V) or the formation of other As species. The influence of storage temperature and time on ATO was evaluated. Low amounts of As(III) to As(V) conversions were observed when the As encapsulated with nanoliposome was incubated at 25 °C and 40 °C. However, As(III) was stable if the solution was maintained at 5 °C, even after 90 days. No formation of other As species was observed, indicating good stability of the encapsulated ATO. Next step of the work will focus on spray drying of ATO nanoliposomes-encapsuleted with the aim of long term stability of As.Entities:
Keywords: Arsenic species; Arsenic trioxide; Liposome
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Year: 2018 PMID： 30472478 DOI： 10.1016/j.leukres.2018.11.008
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156