Literature DB >> 30472104

IP-10 is highly involved in HIV infection.

Jie Lei1, Xiaowan Yin1, Hong Shang2, Yongjun Jiang3.   

Abstract

Interferon-γ (IFN-γ)-induced protein 10 (IP-10 or CXCL-10) is a chemokine involved in trafficking immune cells to inflammatory sites. Numerous studies have reported abnormally high plasma IP-10 levels in the context of human immunodeficiency virus (HIV) infection, and IP-10 is considered an important pro-inflammatory factor in the HIV disease process. The data regarding the roles of IP-10 in HIV infection required collation; this review summarizes the biological characteristics of IP-10, the positive association between plasma IP-10 levels and HIV disease progression, the effect of IP-10 on human immune cells, and potential related mechanisms. This review provides important insights into the role of IP-10 in HIV monitoring and treatment.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  Disease progression; HIV; IP-10 (CXCL-10); Immune cells

Mesh：

Substances：

Year:  2018        PMID： 30472104     DOI： 10.1016/j.cyto.2018.11.018

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  32 in total

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