Jessica O'Connell1, Monica Sunwoo2, Patrick McGorry3, Brian O'Donoghue4. 1. Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia; Orygen Youth Health, 35 Poplar Rd, Parkville, VIC 3025, Australia. 2. Orygen Youth Health, 35 Poplar Rd, Parkville, VIC 3025, Australia. 3. Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia. 4. Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia; Orygen Youth Health, 35 Poplar Rd, Parkville, VIC 3025, Australia. Electronic address: brian.odonoghue@orygen.org.au.
Abstract
BACKGROUND: Substance induced psychotic disorders (SIPD) have been historically considered as associated with better clinical and functional outcomes than other psychotic diagnoses. As a result, treatments for those with SIPD are often considerably less intensive, yet this is not based on evidence. The present study aimed to examine whether differences exist between those with SIPD and other first episode psychosis (FEP) diagnoses in regards to demographic and clinical factors, and to determine the symptomatic, clinical and functional outcomes in those with SIPD. METHODS: This study included all young people aged 15-24 who presented with a FEP to the Early Psychosis Prevention and Intervention Centre between 01/01/2011 and 31/12/2013. Group differences were analysed with independent samples t-tests and chi-square analyses and equivalent non-parametric tests as appropriate. Where applicable, odds ratios were calculated. RESULTS: 544 young people presented with a FEP and 10.3% (N = 56) were diagnosed with SIPD. Individuals with SIPD were more likely to be male, unemployed, and have a comorbid substance use disorder. There were no significant differences between groups regarding duration of untreated psychosis, severity of psychotic symptoms, time to remission, or rates of relapse. Those with SIPD were less likely to be employed or engaged in study at discharge and 35.7% of those with SIPD had a change of diagnosis to a schizophrenia spectrum or bipolar disorder after a median of 84 weeks. CONCLUSION: Young people diagnosed with SIPD should be an important focus of early intervention services and receive comparable treatment to those with other psychotic diagnoses.
BACKGROUND: Substance induced psychotic disorders (SIPD) have been historically considered as associated with better clinical and functional outcomes than other psychotic diagnoses. As a result, treatments for those with SIPD are often considerably less intensive, yet this is not based on evidence. The present study aimed to examine whether differences exist between those with SIPD and other first episode psychosis (FEP) diagnoses in regards to demographic and clinical factors, and to determine the symptomatic, clinical and functional outcomes in those with SIPD. METHODS: This study included all young people aged 15-24 who presented with a FEP to the Early Psychosis Prevention and Intervention Centre between 01/01/2011 and 31/12/2013. Group differences were analysed with independent samples t-tests and chi-square analyses and equivalent non-parametric tests as appropriate. Where applicable, odds ratios were calculated. RESULTS: 544 young people presented with a FEP and 10.3% (N = 56) were diagnosed with SIPD. Individuals with SIPD were more likely to be male, unemployed, and have a comorbid substance use disorder. There were no significant differences between groups regarding duration of untreated psychosis, severity of psychotic symptoms, time to remission, or rates of relapse. Those with SIPD were less likely to be employed or engaged in study at discharge and 35.7% of those with SIPD had a change of diagnosis to a schizophrenia spectrum or bipolar disorder after a median of 84 weeks. CONCLUSION: Young people diagnosed with SIPD should be an important focus of early intervention services and receive comparable treatment to those with other psychotic diagnoses.
Authors: David Beckmann; Kelsey Leigh Lowman; Jessica Nargiso; James McKowen; Lisa Watt; Amy M Yule Journal: Child Adolesc Psychiatr Clin N Am Date: 2019-09-23
Authors: Sidhant Chopra; Alex Fornito; Shona M Francey; Brian O'Donoghue; Vanessa Cropley; Barnaby Nelson; Jessica Graham; Lara Baldwin; Steven Tahtalian; Hok Pan Yuen; Kelly Allott; Mario Alvarez-Jimenez; Susy Harrigan; Kristina Sabaroedin; Christos Pantelis; Stephen J Wood; Patrick McGorry Journal: Neuropsychopharmacology Date: 2021-02-26 Impact factor: 7.853
Authors: Laura von Hardenberg; Karolina Leopold; Nikola Stenzel; Michèle Kallenbach; Navid Aliakbari; Andreas Bechdolf; Stephanie Mehl Journal: Front Psychiatry Date: 2022-09-16 Impact factor: 5.435
Authors: Stefan Siebert; Karolina Leopold; Johanna Baumgardt; Laura-Sophie von Hardenberg; Eva Burkhardt; Andreas Bechdolf Journal: Eur Arch Psychiatry Clin Neurosci Date: 2022-02-09 Impact factor: 5.760