Renata Costa de Miranda1, Nicola Di Lorenzo2, Angela Andreoli3, Lorenzo Romano4, Gemma Lou De Santis4, Paola Gualtieri5, Antonino De Lorenzo6. 1. PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy; CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil. 2. Department of Surgical Sciences, University of Tor Vergata, Policlinico Tor Vergata, Rome, Italy. 3. Department of System Medicine, Human Physiology and Nutrition Unit, University of Rome Tor Vergata, Rome, Italy. 4. Specialisation School of Food Science, University of Rome Tor Vergata, Rome, Italy. 5. PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy. 6. Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and prevention, University of Rome Tor Vergata, Rome, Italy; Casa di Cura Madonna dello Scoglio, Cotronei, Italy. Electronic address: Delorenzo@uniroma2.it.
Abstract
OBJECTIVE: Understanding the body composition (BC) of patients with Huntington's disease (HD) could help to delay disease progression and improve treatment efficacy. The aim of this study was to assess BC parameters, including bone mineral density (BMD), and to find new biomarkers that can be early indicators for weight loss in patients with HD. METHODS: Twenty-one age- and sex-matched patients with HD and 29 healthy controls (CT) were enrolled. For each patient, body weight (BW), height, and body mass index (BMI) were evaluated. BC and BMD were measured by dual-energy x-ray absorptiometry. Subsamples were created according to sex and percent fat mass (FM) (obese and nonobese). All analyses were carried out using SPSS version 23. RESULTS: In all comparisons, BMD and T-score were lower in the HD group, but were not correlated with lean body mass (LBM) or FM. In the HD group, LBM and truncal fat were mostly reduced, except in women with HD whose BC appeared to be less affected by the disease than men. Furthermore, LBM (r = 0.80) and truncal fat (r = 0.68) were better correlated with BW than BMI (r = 0.56). CONCLUSION: Complete BC assessment can be crucial for preventive interventions and prognosis definition in patients with HD. New biomarkers such as BMD, LBM, and truncal fat can be early indicators of weight loss in patients with HD.
OBJECTIVE: Understanding the body composition (BC) of patients with Huntington's disease (HD) could help to delay disease progression and improve treatment efficacy. The aim of this study was to assess BC parameters, including bone mineral density (BMD), and to find new biomarkers that can be early indicators for weight loss in patients with HD. METHODS: Twenty-one age- and sex-matched patients with HD and 29 healthy controls (CT) were enrolled. For each patient, body weight (BW), height, and body mass index (BMI) were evaluated. BC and BMD were measured by dual-energy x-ray absorptiometry. Subsamples were created according to sex and percent fat mass (FM) (obese and nonobese). All analyses were carried out using SPSS version 23. RESULTS: In all comparisons, BMD and T-score were lower in the HD group, but were not correlated with lean body mass (LBM) or FM. In the HD group, LBM and truncal fat were mostly reduced, except in women with HD whose BC appeared to be less affected by the disease than men. Furthermore, LBM (r = 0.80) and truncal fat (r = 0.68) were better correlated with BW than BMI (r = 0.56). CONCLUSION: Complete BC assessment can be crucial for preventive interventions and prognosis definition in patients with HD. New biomarkers such as BMD, LBM, and truncal fat can be early indicators of weight loss in patients with HD.
Authors: Ye Zhang; Rong Ren; Linghui Yang; Junying Zhou; Yun Li; Jie Shi; Lin Lu; Larry D Sanford; Xiangdong Tang Journal: Sleep Date: 2019-10-09 Impact factor: 5.849
Authors: Nimra Hasnain; Taha Bin Arif; Roha Shafaut; Faiza Zakaria; Syeda Zainab Fatima; Ibtehaj Ul Haque Journal: Wien Med Wochenschr Date: 2022-06-20