Borja Martinez-Tellez1,2, Guillermo Sanchez-Delgado1, Juan M A Alcantara1, Francisco M Acosta1, Francisco J Amaro-Gahete1,3, Francisco J Osuna-Prieto1,4,5, Alejandro Perez-Bey6, David Jimenez-Pavon7, Jose M Llamas-Elvira8,9, Angel Gil10,11, Concepcion M Aguilera10,11, Patrick C N Rensen2, Jonatan R Ruiz1. 1. PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. 2. Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. 3. Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain. 4. Department of Analytical Chemistry, University of Granada, Granada, Spain. 5. Research and Development of Functional Food Centre (CIDAF), Health Science Technological Park, Granada, Spain. 6. Galeno research group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 7. MOVE-IT research group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Spain. 8. Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain. 9. Servicio de Medicina Nuclear, Instituto de Investigación Biosanitaria (ibs. GRANADA), Granada, Spain. 10. Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, Granada, Spain. 11. CIBEROBN, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition, Carlos III Health Institute, Madrid, Spain.
Abstract
NEW FINDINGS: What is the central question of this study? In some studies, biopsies have been performed of the subcutaneous adipose tissue in the abdomen, and they failed to find browning markers. Is the abdomen the right place to take biopsies? What is the main finding and its importance? For first time, we observed that the glucose uptake in the dorsocervical subcutaneous adipose tissue is higher in comparison to other areas of subcutaneous adipose tissue. ABSTRACT: Neonates have subcutaneous brown adipose tissue (BAT) in the dorsocervical area, and it is thought that these depots gradually disappear with age. Here, we determined that young adults have high 18 F-flurodeoxyglucose (18 F-FDG) uptake in the subcutaneous adipose tissue (SAT) of the dorsocervical area. A total of 133 young adults (age 22 ± 2 years; body mass index 25 ± 5 kg m2 ) were included in the study. We performed a shivering threshold test for every participant. Later, we performed 2 h of personalized cold exposure, immediately before a positron emission tomography/computed tomography scan. We showed that 23 of 133 participants had 18 F-FDG uptake in the dorsocervical area that achieved the criteria to be considered BAT, mainly in women (96%, n = 22 of 23). In the whole sample, the glucose uptake in the SAT of the dorsocervical area was positively correlated with BAT volume and activity located in the supraclavicular area. We showed that the 18 F-FDG uptake of the SAT of the dorsocervical area in humans is different from that of other SAT areas. Future studies are warranted to confirm the brown signature of this tissue.
NEW FINDINGS: What is the central question of this study? In some studies, biopsies have been performed of the subcutaneous adipose tissue in the abdomen, and they failed to find browning markers. Is the abdomen the right place to take biopsies? What is the main finding and its importance? For first time, we observed that the glucose uptake in the dorsocervical subcutaneous adipose tissue is higher in comparison to other areas of subcutaneous adipose tissue. ABSTRACT: Neonates have subcutaneous brown adipose tissue (BAT) in the dorsocervical area, and it is thought that these depots gradually disappear with age. Here, we determined that young adults have high 18 F-flurodeoxyglucose (18 F-FDG) uptake in the subcutaneous adipose tissue (SAT) of the dorsocervical area. A total of 133 young adults (age 22 ± 2 years; body mass index 25 ± 5 kg m2 ) were included in the study. We performed a shivering threshold test for every participant. Later, we performed 2 h of personalized cold exposure, immediately before a positron emission tomography/computed tomography scan. We showed that 23 of 133 participants had 18 F-FDG uptake in the dorsocervical area that achieved the criteria to be considered BAT, mainly in women (96%, n = 22 of 23). In the whole sample, the glucose uptake in the SAT of the dorsocervical area was positively correlated with BAT volume and activity located in the supraclavicular area. We showed that the 18 F-FDG uptake of the SAT of the dorsocervical area in humans is different from that of other SAT areas. Future studies are warranted to confirm the brown signature of this tissue.
Authors: L Ortiz-Alvarez; F M Acosta; J R Ruiz; B Martinez-Tellez; H Xu; G Sanchez-Delgado; R Vilchez-Vargas; A Link; J Plaza-Díaz; J M Llamas; A Gil; I Labayen; P C N Rensen Journal: J Endocrinol Invest Date: 2022-10-15 Impact factor: 5.467
Authors: Lucas Jurado-Fasoli; Xinyu Di; Isabelle Kohler; Francisco J Osuna-Prieto; Thomas Hankemeier; Elke Krekels; Amy C Harms; Wei Yang; Jose V Garcia-Lario; Sonia Fernández-Veledo; Jonatan R Ruiz; Patrick C N Rensen; Borja Martinez-Tellez Journal: Obesity (Silver Spring) Date: 2021-12-12 Impact factor: 9.298
Authors: Laura A Fletcher; Katherine Kim; Brooks P Leitner; Thomas M Cassimatis; Alana E O'Mara; James W Johnson; Molly S Halprin; Suzanne M McGehee; Robert J Brychta; Aaron M Cypess; Kong Y Chen Journal: Obesity (Silver Spring) Date: 2020-02 Impact factor: 9.298