D W Bartenstein1,2,3,4, J M Fisher1,4, C Stamoulis1,5, C Weldon1,6,7, J T Huang1,4,7, S E Gellis1,4, M G Liang1,4, B Schmidt1,8, E B Hawryluk1,2,4. 1. Harvard Medical School, Boston, MA, 02115, U.S.A. 2. Department of Dermatology, Massachusetts General Hospital, Boston, MA, 02114, U.S.A. 3. Tufts University School of Medicine, Boston, MA, 02111, U.S.A. 4. Dermatology Program, Boston Children's Hospital, Boston, MA, 02115, U.S.A. 5. Division of Adolescent Medicine, Boston Children's Hospital, Boston, MA, 02115, U.S.A. 6. Department of Surgery, Boston Children's Hospital, Boston, MA, 02115, U.S.A. 7. Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, 02215, U.S.A. 8. Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, U.S.A.
Abstract
BACKGROUND: Spitzoid proliferations range from Spitz naevi to melanomas. There are few studies describing clinical features and outcomes in the paediatric population. OBJECTIVES: To determine the clinical features and outcomes of a large paediatric cohort with histopathologically confirmed Spitz tumours. METHODS: This was a retrospective cohort study of patients seen at Boston Children's Hospital who were aged < 20 years and had a histopathological diagnosis of spitzoid proliferation from 1 January 1994 to 23 October 2012. RESULTS: In total 595 patients with 622 spitzoid proliferations were identified (median age 7·4 years, interquartile range 4·6-11·7). Overall 512 proliferations (82·3%) were typical, 107 (17·2.%) were atypical and three (0·5%) were melanomas. The median ages at biopsy were 7·4, 7·2 and 17·2 years, respectively, and there was a significant difference in age at biopsy for patients with typical or atypical proliferations vs. melanoma (P < 0·01). Among samples with positive margins (n = 153), 55% (54 of 98) of typical proliferations, 77% (41 of 53) of atypical proliferations and 100% (two of two) of melanomas were re-excised. Six patients had sentinel lymph node biopsy performed, with three patients demonstrating nodes positive for melanocytic cells. Within a median follow-up of 4·1 years for the full cohort there were no related deaths. CONCLUSIONS: Spitz tumours have strikingly benign outcomes in the paediatric population, although this study is limited by the low number of melanomas and restriction to a single paediatric institution. Aggressive management recommendations should be reconsidered for children and adolescents with banal-appearing Spitz naevi, based on the clinically indolent behaviour in this cohort.
BACKGROUND:Spitzoid proliferations range from Spitz naevi to melanomas. There are few studies describing clinical features and outcomes in the paediatric population. OBJECTIVES: To determine the clinical features and outcomes of a large paediatric cohort with histopathologically confirmed Spitz tumours. METHODS: This was a retrospective cohort study of patients seen at Boston Children's Hospital who were aged < 20 years and had a histopathological diagnosis of spitzoid proliferation from 1 January 1994 to 23 October 2012. RESULTS: In total 595 patients with 622 spitzoid proliferations were identified (median age 7·4 years, interquartile range 4·6-11·7). Overall 512 proliferations (82·3%) were typical, 107 (17·2.%) were atypical and three (0·5%) were melanomas. The median ages at biopsy were 7·4, 7·2 and 17·2 years, respectively, and there was a significant difference in age at biopsy for patients with typical or atypical proliferations vs. melanoma (P < 0·01). Among samples with positive margins (n = 153), 55% (54 of 98) of typical proliferations, 77% (41 of 53) of atypical proliferations and 100% (two of two) of melanomas were re-excised. Six patients had sentinel lymph node biopsy performed, with three patients demonstrating nodes positive for melanocytic cells. Within a median follow-up of 4·1 years for the full cohort there were no related deaths. CONCLUSIONS:Spitz tumours have strikingly benign outcomes in the paediatric population, although this study is limited by the low number of melanomas and restriction to a single paediatric institution. Aggressive management recommendations should be reconsidered for children and adolescents with banal-appearing Spitz naevi, based on the clinically indolent behaviour in this cohort.
Authors: Leon Raskin; Mathew Ludgate; Ramaswamy K Iyer; Todd E Ackley; Carol R Bradford; Timothy M Johnson; Douglas R Fullen Journal: Am J Surg Pathol Date: 2011-02 Impact factor: 6.394
Authors: R L Barnhill; Z B Argenyi; L From; L F Glass; J C Maize; M C Mihm; M S Rabkin; S G Ronan; W L White; M Piepkorn Journal: Hum Pathol Date: 1999-05 Impact factor: 3.466
Authors: David R Berk; Elizabeth LaBuz; Soheil S Dadras; Denise L Johnson; Susan M Swetter Journal: Pediatr Dermatol Date: 2010-04-09 Impact factor: 1.588
Authors: Usha E A Beijnen; Landis R Walsh; Laura C Nuzzi; Birgitta A R Schmidt; Brian I Labow; Amir H Taghinia Journal: Plast Reconstr Surg Glob Open Date: 2020-12-18
Authors: Jeffrey K Mito; Margaret C Weber; Alexandra Corbin; George F Murphy; Leonard I Zon Journal: Dis Model Mech Date: 2022-08-26 Impact factor: 5.732