Volkan Yilmaz1, Ebru Umay2, Ibrahim Gundogdu2, Fatma Aytul Cakcı2. 1. Physical Rehabilitation Medicine Clinic, Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. dryilmazv@hotmail.com. 2. Physical Rehabilitation Medicine Clinic, Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Abstract
AIM: To investigate the efficacy of primary hypertension (HTN) on the treatment prognosis of patients with postmenopausal osteoporosis (PMOP). METHODS: 45 patients who were diagnosed as PMOP with lumbar and/or femur neck bone mineral density screening (BMD) but have no history of PMOP treatment including calcium and vitamin D, have comorbid primary HTN and treated with a vasodilator antihypertensive drug at least a year were included to the study. Control group was constituted with 44 patients with PMOP at same age but have no comorbidity. Demographic features including age, height, weight, occupation, educational level menarche and menopause age, clothing style, daily intake of calcium, smoking and/or alcohol consumption, daily physical activity level, personal history of fragility fracture or in mother and duration of primary HTN diagnosis were recorded. Biochemical parameters were also recorded. Patients were treated with bisphosphonate, calcium and vitamin D and same parameters were evaluated at the end of first and fifth year. RESULTS: Demographic and disease characteristics were not different between groups before treatment (p > 0.05). In group analysis, there was significant improvement in lumbar and femur neck T scores of PMOP + HT and PMOP groups after 1 and 5 years of treatment compared to baseline (p < 0.05) Lumbar and femur neck T score variations between the baseline, first and fifth years of treatment were not significantly different in PMOP + HT and PMOP groups (p < 0.05). CONCLUSIONS: Although the results vary between populations, primary HTN does not have an impact on the prognosis of PMOP treatment in Turkish population.
AIM: To investigate the efficacy of primary hypertension (HTN) on the treatment prognosis of patients with postmenopausal osteoporosis (PMOP). METHODS: 45 patients who were diagnosed as PMOP with lumbar and/or femur neck bone mineral density screening (BMD) but have no history of PMOP treatment including calcium and vitamin D, have comorbid primary HTN and treated with a vasodilator antihypertensive drug at least a year were included to the study. Control group was constituted with 44 patients with PMOP at same age but have no comorbidity. Demographic features including age, height, weight, occupation, educational level menarche and menopause age, clothing style, daily intake of calcium, smoking and/or alcohol consumption, daily physical activity level, personal history of fragility fracture or in mother and duration of primary HTN diagnosis were recorded. Biochemical parameters were also recorded. Patients were treated with bisphosphonate, calcium and vitamin D and same parameters were evaluated at the end of first and fifth year. RESULTS: Demographic and disease characteristics were not different between groups before treatment (p > 0.05). In group analysis, there was significant improvement in lumbar and femur neck T scores of PMOP + HT and PMOP groups after 1 and 5 years of treatment compared to baseline (p < 0.05) Lumbar and femur neck T score variations between the baseline, first and fifth years of treatment were not significantly different in PMOP + HT and PMOP groups (p < 0.05). CONCLUSIONS: Although the results vary between populations, primary HTN does not have an impact on the prognosis of PMOP treatment in Turkish population.
Authors: J L Pérez-Castrillón; I Justo; J Silva; A Sanz; R Igea; P Escudero; C Pueyo; C Diaz; G Hernández; A Dueñas Journal: J Hum Hypertens Date: 2003-02 Impact factor: 3.012
Authors: Thais Francini Garbieri; Victor Martin; Carlos Ferreira Santos; Pedro de Sousa Gomes; Maria Helena Fernandes Journal: Pharmaceuticals (Basel) Date: 2021-05-16