Literature DB >> 3046614

Host-cell attachment by Trypanosoma cruzi: identification of an adhesion molecule.

M F Lima1, F Villalta.   

Abstract

We have identified an 83 kDa surface glycoprotein in T. cruzi trypomastigotes which specifically binds to rat heart myoblasts. The binding of this molecule to myoblasts is inhibited by excess unlabeled material and saturable. Antibodies against the cell surface of insect trypomastigotes, blood trypomastigotes and produced during human infection recognize the 83 kDa glycoprotein adhesion molecule by immunoblotting, indicating that this molecule that mediates this critical step is immunogenic and is a candidate for vaccination against Chagas' disease.

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Year:  1988        PMID： 3046614     DOI： 10.1016/s0006-291x(88)81077-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Characterization of the cell adhesion site of Trypanosoma cruzi metacyclic stage surface glycoprotein gp82.

Authors:  P M Manque; D Eichinger; M A Juliano; L Juliano; J E Araya; N Yoshida
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

Review 2.  Chagas disease.

Authors:  A R L Teixeira; N Nitz; M C Guimaro; C Gomes; C A Santos-Buch
Journal:  Postgrad Med J       Date:  2006-12       Impact factor: 2.401

3.  Purification of a Trypanosoma cruzi trypomastigote 60-kilodalton surface glycoprotein that primes and activates murine lymphocytes.

Authors:  F Villalta; M F Lima; S A Howard; L Zhou; A Ruiz-Ruano
Journal:  Infect Immun       Date:  1992-08       Impact factor: 3.441

4.  Review on Trypanosoma cruzi: Host Cell Interaction.

Authors:  Wanderley de Souza; Tecia Maria Ulisses de Carvalho; Emile Santos Barrias
Journal:  Int J Cell Biol       Date:  2010-07-29

Review 5.  Perspectives on the Trypanosoma cruzi-host cell receptor interactions.

Authors:  Fernando Villalta; Julio Scharfstein; Anthony W Ashton; Kevin M Tyler; Fangxia Guan; Shankar Mukherjee; Maria F Lima; Sandra Alvarez; Louis M Weiss; Huan Huang; Fabiana S Machado; Herbert B Tanowitz
Journal:  Parasitol Res       Date:  2009-03-13       Impact factor: 2.289

6.  Further characterization of protective Trypanosoma cruzi-specific CD4+ T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens.

Authors:  S P Nickell; M Keane; M So
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

Review 7.  Molecular analysis of early host cell infection by Trypanosoma cruzi.

Authors:  Fernando Villalta; M Nia Madison; Yuliya Y Kleshchenko; Pius N Nde; Maria F Lima
Journal:  Front Biosci       Date:  2008-05-01

8.  Biochemical and immunological characterization of major surface antigens of Sarcocystis muris and S. suicanis cyst merozoites.

Authors:  I Sommer; H Mehlhorn; W Rüger
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

9.  The cysteine-cysteine family of chemokines RANTES, MIP-1alpha, and MIP-1beta induce trypanocidal activity in human macrophages via nitric oxide.

Authors:  F Villalta; Y Zhang; K E Bibb; J C Kappes; M F Lima
Journal:  Infect Immun       Date:  1998-10       Impact factor: 3.441

10.  Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection.

Authors:  Pius N Nde; Maria F Lima; Candice A Johnson; Siddharth Pratap; Fernando Villalta
Journal:  Front Immunol       Date:  2012-11-06       Impact factor: 7.561
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