Literature DB >> 30466054

The effect of varying the number of contributors in the prosecution and alternate propositions.

John S Buckleton1, Jo-Anne Bright2, Kevin Cheng2, Hannah Kelly2, Duncan A Taylor3.   

Abstract

Using a simplified model, we examine the effect of varying the number of contributors in the prosecution and alternate propositions for a number of simulated examples. We compare the Slooten and Caliebe [1] solution, with several existing practices. Our own experience is that most laboratories, and ourselves, assign the number of contributors, N = n, by allele count and a manual examination of peak heights. The LRn for one or a very few values is calculated and typically one of these is presented, usually the most conservative. This gives an acceptable approximation. Reassessing the number of contributors if LR = 0 and adding one to N under both Hp and Ha to "fit" the POI may lead to a substantial overstatement of the LR. A more reasonable option is to allow optimisation of the assignment under Hp and Ha separately. We show that an additional contributor explained the single locus profile better when PHR≥0.51. This is pleasingly in line with current interpretation approaches. Collectively these trials, and the solid theoretical development, suggest that the Slooten and Caliebe approach preforms well.
Copyright © 2018 Elsevier B.V. All rights reserved.

Keywords:  DNA mixture interpretation; Number of contributors; Slooten and Caliebe

Mesh:

Substances:

Year:  2018        PMID: 30466054     DOI: 10.1016/j.fsigen.2018.11.011

Source DB:  PubMed          Journal:  Forensic Sci Int Genet        ISSN: 1872-4973            Impact factor:   4.882


  2 in total

Review 1.  A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™.

Authors:  Peter Gill; Corina Benschop; John Buckleton; Øyvind Bleka; Duncan Taylor
Journal:  Genes (Basel)       Date:  2021-09-30       Impact factor: 4.096

2.  Internal Validation of MaSTR™ Probabilistic Genotyping Software for the Interpretation of 2-5 Person Mixed DNA Profiles.

Authors:  Michael S Adamowicz; Taylor N Rambo; Jennifer L Clarke
Journal:  Genes (Basel)       Date:  2022-08-11       Impact factor: 4.141

  2 in total

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