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Literature DB >> 30464734

A Metabolic Paradigm for Epilepsy.

Abstract

There is a resurgence of interest in the role of metabolism in epilepsy. Long considered ancillary and acknowledged only in the context of clinical application of ketogenic diets, metabolic control of epilepsy is gaining momentum and mainstream interest among researchers. A metabolic paradigm for epilepsy rests upon known perturbations in three major interconnected metabolic nodes and therapeutic targets therefrom (i.e., glycolysis, mitochondria, and redox balance).

Entities: Disease

Year: 2018 PMID： 30464734 PMCID： PMC6224150 DOI： 10.5698/1535-7597.18.5.318

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

65 in total

Review 1. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

Authors: Barry Halliwell; Matthew Whiteman
Journal: Br J Pharmacol Date: 2004-05 Impact factor: 8.739

2. Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase.

Authors: Tanya S McDonald; Karin Borges
Journal: Epilepsia Date: 2017-06-20 Impact factor: 5.864

3. Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.

Authors: Nagisa Sada; Suni Lee; Takashi Katsu; Takemi Otsuki; Tsuyoshi Inoue
Journal: Science Date: 2015-03-20 Impact factor: 47.728

4. Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective.

Authors: S Williams; N Hamil; A Y Abramov; M C Walker; S Kovac
Journal: Neuroscience Date: 2015-07-07 Impact factor: 3.590

5. Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure.

Authors: Nikolaos Patsoukis; George Zervoudakis; Christos D Georgiou; Fevronia Angelatou; Nikolaos A Matsokis; Nikolaos T Panagopoulos
Journal: Epilepsia Date: 2005-08 Impact factor: 5.864

6. Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid.

Authors: Jaroslava Folbergrová; Pavel Jesina; Renata Haugvicová; Václav Lisý; Josef Houstek
Journal: Neurochem Int Date: 2009-11-18 Impact factor: 3.921

7. Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'.

Authors: Sonya Bahar; Minah Suh; Mingrui Zhao; Theodore H Schwartz
Journal: Neuroreport Date: 2006-04-03 Impact factor: 1.837

8. Intrastriatal malonate administration induces convulsive behaviour in rats.

Authors: J Fleck; M C P Ribeiro; C M Schneider; V D G Sinhorin; M A Rubin; C F Mello
Journal: J Inherit Metab Dis Date: 2004 Impact factor: 4.982

9. Alterations in Cytosolic and Mitochondrial [U-¹³C]Glucose Metabolism in a Chronic Epilepsy Mouse Model.

Authors: Tanya S McDonald; Catalina Carrasco-Pozo; Mark P Hodson; Karin Borges
Journal: eNeuro Date: 2017-03-09

10. Measurement of Local Partial Pressure of Oxygen in the Brain Tissue under Normoxia and Epilepsy with Phosphorescence Lifetime Microscopy.

Authors: Cong Zhang; Samuel Bélanger; Philippe Pouliot; Frédéric Lesage
Journal: PLoS One Date: 2015-08-25 Impact factor: 3.240

13 in total

1. Novel mutation of SIK1 gene causing a mild form of pediatric epilepsy in a Chinese patient.

Authors: Wangshu Xu; Wenqun Zhang; Lili Cui; Lei Shi; Bin Zhu; Tina-Jie Lyu; Wenping Ma
Journal: Metab Brain Dis Date: 2022-03-10 Impact factor: 3.584

2. An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy.

Authors: Anna Harutyunyan; Debbie Chong; Rui Li; Anup D Shah; Zahra Ali; Cheng Huang; Christopher K Barlow; Piero Perucca; Terence J O'Brien; Nigel C Jones; Ralf B Schittenhelm; Alison Anderson; Pablo M Casillas-Espinosa
Journal: Int J Mol Sci Date: 2022-05-28 Impact factor: 6.208

A Metabolic Paradigm for Epilepsy.

Review 1. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

2. Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase.

3. Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.

4. Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective.

5. Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure.

6. Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid.

7. Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'.

8. Intrastriatal malonate administration induces convulsive behaviour in rats.

9. Alterations in Cytosolic and Mitochondrial [U-¹³C]Glucose Metabolism in a Chronic Epilepsy Mouse Model.

10. Measurement of Local Partial Pressure of Oxygen in the Brain Tissue under Normoxia and Epilepsy with Phosphorescence Lifetime Microscopy.

1. Novel mutation of SIK1 gene causing a mild form of pediatric epilepsy in a Chinese patient.

2. An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy.

Review 3. Unifying mechanism behind the onset of acquired epilepsy.

4. Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions.

5. Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression.

6. Mom Controls the Thermostat: Mitochondria Influence the Neuronal Firing Set Point.

7. Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome.

8. Variability of seizure-like activity in an in vitro model of epilepsy depends on the electrical recording method.

9. Glucose-Sparing Action of Ketones Boosts Functions Exclusive to Glucose in the Brain.

10. In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia.