Literature DB >> 30464687

Current landscape of immunotherapy in the treatment of solid tumours, with future opportunities and challenges.

N A Nixon1, N Blais2, S Ernst3, C Kollmannsberger4, G Bebb1, M Butler5, M Smylie6, S Verma1.   

Abstract

Immunotherapy has emerged as a new standard of care, showing survival benefit for solid tumours in multiple disease sites and indications. The survival improvements seen in diseases that were highly resistant to traditional therapies, with a poor prognosis, are unprecedented. Although the benefits observed in clinical trials are undeniable, not all patients derive those benefits, leading to emerging combination strategies and an ongoing quest for biomarker selection. Here, we summarize the current evidence for immunotherapy in the treatment of solid tumours, and we discuss emerging strategies at the forefront of research. We discuss future challenges that will be encountered as experience and knowledge continue to expand in this rapidly emerging field.

Entities:  

Keywords:  Immuno-oncology

Mesh:

Substances:

Year:  2018        PMID: 30464687      PMCID: PMC6209564          DOI: 10.3747/co.25.3840

Source DB:  PubMed          Journal:  Curr Oncol        ISSN: 1198-0052            Impact factor:   3.677


  51 in total

1.  Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.

Authors:  Dung T Le; Andrea Wang-Gillam; Vincent Picozzi; Tim F Greten; Todd Crocenzi; Gregory Springett; Michael Morse; Herbert Zeh; Deirdre Cohen; Robert L Fine; Beth Onners; Jennifer N Uram; Daniel A Laheru; Eric R Lutz; Sara Solt; Aimee Luck Murphy; Justin Skoble; Ed Lemmens; John Grous; Thomas Dubensky; Dirk G Brockstedt; Elizabeth M Jaffee
Journal:  J Clin Oncol       Date:  2015-01-12       Impact factor: 44.544

2.  Ipilimumab in 2nd line treatment of patients with advanced melanoma: a cost-effectiveness analysis.

Authors:  Victor Barzey; Michael B Atkins; Louis P Garrison; Yumi Asukai; Srividya Kotapati; John R Penrod
Journal:  J Med Econ       Date:  2012-11-01       Impact factor: 2.448

3.  Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

Authors:  Roy S Herbst; Jean-Charles Soria; Marcin Kowanetz; Gregg D Fine; Omid Hamid; Michael S Gordon; Jeffery A Sosman; David F McDermott; John D Powderly; Scott N Gettinger; Holbrook E K Kohrt; Leora Horn; Donald P Lawrence; Sandra Rost; Maya Leabman; Yuanyuan Xiao; Ahmad Mokatrin; Hartmut Koeppen; Priti S Hegde; Ira Mellman; Daniel S Chen; F Stephen Hodi
Journal:  Nature       Date:  2014-11-27       Impact factor: 49.962

4.  Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study.

Authors:  Thomas J Lynch; Igor Bondarenko; Alexander Luft; Piotr Serwatowski; Fabrice Barlesi; Raju Chacko; Martin Sebastian; Joel Neal; Haolan Lu; Jean-Marie Cuillerot; Martin Reck
Journal:  J Clin Oncol       Date:  2012-04-30       Impact factor: 44.544

5.  Standard-dose pembrolizumab in combination with reduced-dose ipilimumab for patients with advanced melanoma (KEYNOTE-029): an open-label, phase 1b trial.

Authors:  Georgina V Long; Victoria Atkinson; Jonathan S Cebon; Michael B Jameson; Bernie M Fitzharris; Catriona M McNeil; Andrew G Hill; Antoni Ribas; Michael B Atkins; John A Thompson; Wen-Jen Hwu; F Stephen Hodi; Alexander M Menzies; Alexander D Guminski; Richard Kefford; Benjamin Y Kong; Babak Tamjid; Archana Srivastava; Anna J Lomax; Mohammed Islam; Xinxin Shu; Scot Ebbinghaus; Nageatte Ibrahim; Matteo S Carlino
Journal:  Lancet Oncol       Date:  2017-07-17       Impact factor: 41.316

6.  Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria.

Authors:  Jedd D Wolchok; Axel Hoos; Steven O'Day; Jeffrey S Weber; Omid Hamid; Celeste Lebbé; Michele Maio; Michael Binder; Oliver Bohnsack; Geoffrey Nichol; Rachel Humphrey; F Stephen Hodi
Journal:  Clin Cancer Res       Date:  2009-11-24       Impact factor: 12.531

7.  Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer.

Authors:  Hossein Borghaei; Luis Paz-Ares; Leora Horn; David R Spigel; Martin Steins; Neal E Ready; Laura Q Chow; Everett E Vokes; Enriqueta Felip; Esther Holgado; Fabrice Barlesi; Martin Kohlhäufl; Oscar Arrieta; Marco Angelo Burgio; Jérôme Fayette; Hervé Lena; Elena Poddubskaya; David E Gerber; Scott N Gettinger; Charles M Rudin; Naiyer Rizvi; Lucio Crinò; George R Blumenschein; Scott J Antonia; Cécile Dorange; Christopher T Harbison; Friedrich Graf Finckenstein; Julie R Brahmer
Journal:  N Engl J Med       Date:  2015-09-27       Impact factor: 91.245

8.  Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.

Authors:  Jedd D Wolchok; Vanna Chiarion-Sileni; Rene Gonzalez; Piotr Rutkowski; Jean-Jacques Grob; C Lance Cowey; Christopher D Lao; John Wagstaff; Dirk Schadendorf; Pier F Ferrucci; Michael Smylie; Reinhard Dummer; Andrew Hill; David Hogg; John Haanen; Matteo S Carlino; Oliver Bechter; Michele Maio; Ivan Marquez-Rodas; Massimo Guidoboni; Grant McArthur; Celeste Lebbé; Paolo A Ascierto; Georgina V Long; Jonathan Cebon; Jeffrey Sosman; Michael A Postow; Margaret K Callahan; Dana Walker; Linda Rollin; Rafia Bhore; F Stephen Hodi; James Larkin
Journal:  N Engl J Med       Date:  2017-09-11       Impact factor: 91.245

9.  Monitoring PD-L1 positive circulating tumor cells in non-small cell lung cancer patients treated with the PD-1 inhibitor Nivolumab.

Authors:  Chiara Nicolazzo; Cristina Raimondi; MariaLaura Mancini; Salvatore Caponnetto; Angela Gradilone; Orietta Gandini; Maria Mastromartino; Gabriella Del Bene; Alessandra Prete; Flavia Longo; Enrico Cortesi; Paola Gazzaniga
Journal:  Sci Rep       Date:  2016-08-24       Impact factor: 4.379

10.  Immune-related response criteria: light and shadows.

Authors:  Marco Merlano; Marcella Occelli; Ornella Garrone
Journal:  ESMO Open       Date:  2016-07-07
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  38 in total

1.  Immune checkpoint inhibitors in cancer immunotherapy.

Authors:  Megan E Himmel; Samuel D Saibil; Alexandra P Saltman
Journal:  CMAJ       Date:  2020-06-15       Impact factor: 8.262

Review 2.  Immune checkpoint blockade in solid organ tumours: Choice, dose and predictors of response.

Authors:  Vishal Navani; Moira C Graves; Nikola A Bowden; Andre Van Der Westhuizen
Journal:  Br J Clin Pharmacol       Date:  2020-06-05       Impact factor: 4.335

Review 3.  The future of microfluidics in immune checkpoint blockade.

Authors:  Jonathan Briones; Wilfred Espulgar; Shohei Koyama; Hyota Takamatsu; Eiichi Tamiya; Masato Saito
Journal:  Cancer Gene Ther       Date:  2020-10-27       Impact factor: 5.987

4.  Phase I Study of Tremelimumab Monotherapy or in Combination With Durvalumab in Japanese Patients With Advanced Solid Tumors or Malignant Mesothelioma.

Authors:  Yutaka Fujiwara; Yasuo Takahashi; Morihito Okada; Takumi Kishimoto; Shunsuke Kondo; Koshi Fujikawa; Manabu Hayama; Masatoshi Sugeno; Shinya Ueda; Keiko Komuro; Mark Lanasa; Takashi Nakano
Journal:  Oncologist       Date:  2022-09-02       Impact factor: 5.837

5.  Clinicopathological characteristics and prognostic significance of HDAC11 protein expression in non-small cell lung cancer: a retrospective study.

Authors:  Di Lu; Zhiqiang Ma; Di Huang; Jundong Zhang; Jinfeng Li; Peng Zhi; Lizhong Zhang; Yingtong Feng; Xiangwei Ge; Jinzhao Zhai; Menglong Jiang; Xin Zhou; Charles B Simone; Joel W Neal; Shruti Rajesh Patel; Xiaolong Yan; Yi Hu; Jinliang Wang
Journal:  Transl Lung Cancer Res       Date:  2022-06

6.  Sarcopenia and high NLR are associated with the development of hyperprogressive disease after second-line pembrolizumab in patients with non-small-cell lung cancer.

Authors:  M P Petrova; I S Donev; M A Radanova; M I Eneva; E G Dimitrova; G N Valchev; V T Minchev; M S Taushanova; M V Boneva; T S Karanikolova; R B Gencheva; G A Zhbantov; A I Ivanova; C V Timcheva; B P Pavlov; V G Megdanova; B S Robev; N V Conev
Journal:  Clin Exp Immunol       Date:  2020-08-26       Impact factor: 4.330

7.  The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434).

Authors:  Toshihiko Doi; Yutaka Fujiwara; Kohei Shitara; Toshio Shimizu; Kan Yonemori; Nobuaki Matsubara; Izumi Ohno; Takahiro Kogawa; Yoichi Naito; Lance Leopold; Mihaela Munteanu; Naoyoshi Yatsuzuka; Shi Rong Han; Ayman Samkari; Noboru Yamamoto
Journal:  Invest New Drugs       Date:  2020-06-20       Impact factor: 3.850

8.  Safety and tolerability of Miltuximab® - a first in human study in patients with advanced solid cancers.

Authors:  Dhanusha Sabanathan; Douglas H Campbell; Vicki M Velonas; Sandra Wissmueller; Hubert Mazure; Marko Trifunovic; Pirooz Poursoltan; Kevin Ho Shon; Tiffany R Mackay; Maria E Lund; Yanling Lu; Paul J Roach; Dale L Bailey; Bradley J Walsh; David Gillatt; Howard Gurney
Journal:  Asia Ocean J Nucl Med Biol       Date:  2021

9.  Immune-Related Gene Expression Analysis Revealed Three lncRNAs as Prognostic Factors for Colon Cancer.

Authors:  Xiao-Liang Xing; Ti Zhang; Zhi-Yong Yao; Chaoqun Xing; Chunxiao Wang; Yuan-Wu Liu; Minjiang Huang
Journal:  Front Genet       Date:  2021-07-09       Impact factor: 4.599

10.  Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component.

Authors:  Shirong Zhang; Yang Xu; Pan Zhao; Hua Bao; Xiyong Wang; Rui Liu; Rujun Xu; Jingjing Xiang; Hong Jiang; Junrong Yan; Xue Wu; Yang Shao; Jiafeng Liang; Qiong Wu; Zhihao Zhang; Shun Lu; Shenglin Ma
Journal:  Front Oncol       Date:  2021-06-17       Impact factor: 6.244

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