Suleyman Sami Cakir1, Levent Ozcan2, Emre Can Polat1, Huseyin Besiroglu3, Ramazan Kocaaslan4, Alper Ötunctemur1, Emin Ozbek5. 1. Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey. 2. Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey. 3. Depatment of Urology, Catalca State Hospital, Istanbul, Turkey. 4. Department of Urology, Kafkas University School of Medicine, Kars, Turkey. 5. Department of Urology, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey.
Abstract
OBJECTIVE: To compare the efficacy of statins and ɑ blockers drug therapies for benign prostatic hyperplasia (BPH) in patients with metabolic syndrome (MetS). MATERIALS AND METHOD: A total of three hundred patients were randomly distributed into three groups of one hundred patients each. Group 1 received only ɑ-adrenoceptor antagonist (ɑ-blocker, AB) (Tamsulosin), group 2 received only statin (atorvastatin), and group 3 received AB plus statin (Tamsulosin + Atorvastatin). The efficacy measurement was assessed by analyzing the changes from baseline in the total International Prostate Symptom Score (IPSS), disease-specific QoL question score and maximum urinary flow rate at the end of 6 months in each group and between the three groups. RESULTS: Pre-treatment and post-treatment value of triglycerides (TG), high-density lipoprotein (HDL), and prostate volüme (PV) were not significantly different in AB group, while TG and PV were significantly lower in patients taking statin and combined therapy. The significant decrease was demonstrated in maximum urinary flow rate (Qmax) in three groups. However, the most significant decrease was observed in the combination therapy group. IPSS, postvoid residual urine volüme (PVR), and Quality of Life score (QoL) significantly changed in three groups. CONCLUSION: We recommend of the use of statins in those men with BPH accompanied by MetS in which AB is ineffective alone.
OBJECTIVE: To compare the efficacy of statins and ɑ blockers drug therapies for benign prostatic hyperplasia (BPH) in patients with metabolic syndrome (MetS). MATERIALS AND METHOD: A total of three hundred patients were randomly distributed into three groups of one hundred patients each. Group 1 received only ɑ-adrenoceptor antagonist (ɑ-blocker, AB) (Tamsulosin), group 2 received only statin (atorvastatin), and group 3 received AB plus statin (Tamsulosin + Atorvastatin). The efficacy measurement was assessed by analyzing the changes from baseline in the total International Prostate Symptom Score (IPSS), disease-specific QoL question score and maximum urinary flow rate at the end of 6 months in each group and between the three groups. RESULTS: Pre-treatment and post-treatment value of triglycerides (TG), high-density lipoprotein (HDL), and prostate volüme (PV) were not significantly different in AB group, while TG and PV were significantly lower in patients taking statin and combined therapy. The significant decrease was demonstrated in maximum urinary flow rate (Qmax) in three groups. However, the most significant decrease was observed in the combination therapy group. IPSS, postvoid residual urine volüme (PVR), and Quality of Life score (QoL) significantly changed in three groups. CONCLUSION: We recommend of the use of statins in those men with BPH accompanied by MetS in which AB is ineffective alone.
Authors: Emma H Allott; Ilona Csizmadi; Lauren E Howard; Roberto L Muller; Daniel M Moreira; Gerald L Andriole; Claus G Roehrborn; Stephen J Freedland Journal: BJU Int Date: 2019-09-27 Impact factor: 5.588
Authors: Giorgio Ivan Russo; Gaetano Larganà; Arcangelo Sebastianelli; Andrea Cocci; Marina Di Mauro; Ilenia Rapallo; Giuseppe Morgia; Matteo Mario Morgia; Sandro La Vignera; Rosita Condorelli; Aldo E Calogero; Iacopo Olivotto; Simone Morselli; Sergio Serni; Mauro Gacci Journal: J Clin Med Date: 2021-01-22 Impact factor: 4.241