Wenxiu Chang1, Wenyu Zhang2, Xichao Wang2, Ying Liu2, Yingying Han2, Yangke Tu2, Shunya Uchida3. 1. Department of Nephrology, Tianjin First Center Hospital, Tianjin, China, changwx@sina.com. 2. Department of Nephrology, Tianjin First Center Hospital, Tianjin, China. 3. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Abstract
BACKGROUND: Time-averaged uric acid (TA-UA) value was calculated to investigate the association of longitudinal UA and all-cause mortality in incident peritoneal dialysis (PD) patients. METHODS: Three hundred PD patients were divided into 3 groups based on the serum TA-UA level (Group 1: < 6 mg/dL; Group 2: 6-8 mg/dL; Group 3: ≥8 mg/dL). Hazards ratio (HR) of all-cause mortality was calculated. Logistic regression was conducted to identify the associated clinical factors of lower and higher TA-UA level. RESULTS: Increased HRs for death existed in Group 1 and Group 3 compared with Group 2 (HR 3.24, 95% CI 1.25-8.39, p = 0.016; HR 4.69, 95% CI 1.24-17.72, p = 0.023). Lower residual renal function, lower albumin, and higher high-density lipoprotein cholesterol were related to the lower serum TA-UA. Higher body mass index and higher C-reactive protein were associated with higher serum TA-UA in PD patients. CONCLUSION: Both TA-UA < 6 and ≥8 mg/dL increased the all-cause mortality in incident PD patients.
BACKGROUND: Time-averaged uric acid (TA-UA) value was calculated to investigate the association of longitudinal UA and all-cause mortality in incident peritoneal dialysis (PD) patients. METHODS: Three hundred PDpatients were divided into 3 groups based on the serum TA-UA level (Group 1: < 6 mg/dL; Group 2: 6-8 mg/dL; Group 3: ≥8 mg/dL). Hazards ratio (HR) of all-cause mortality was calculated. Logistic regression was conducted to identify the associated clinical factors of lower and higher TA-UA level. RESULTS: Increased HRs for death existed in Group 1 and Group 3 compared with Group 2 (HR 3.24, 95% CI 1.25-8.39, p = 0.016; HR 4.69, 95% CI 1.24-17.72, p = 0.023). Lower residual renal function, lower albumin, and higher high-density lipoprotein cholesterol were related to the lower serum TA-UA. Higher body mass index and higher C-reactive protein were associated with higher serum TA-UA in PDpatients. CONCLUSION: Both TA-UA < 6 and ≥8 mg/dL increased the all-cause mortality in incident PDpatients.
Authors: Guansen Huang; Yi Wang; Yingfeng Shi; Xiaoyan Ma; Min Tao; Xiujuan Zang; Yinghui Qi; Cheng Qiao; Lin Du; Lili Sheng; Shougang Zhuang; Na Liu Journal: J Cell Mol Med Date: 2021-07-26 Impact factor: 5.310