Literature DB >> 30462104

A pH-driven ring translocation switch against cancer cells.

Qian Cheng1, Hang Yin, Roselyne Rosas, Didier Gigmes, Olivier Ouari, Ruibing Wang, Anthony Kermagoret, David Bardelang.   

Abstract

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

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Year:  2018        PMID: 30462104     DOI: 10.1039/c8cc08681h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology.

Authors:  Debapratim Das; Khaleel I Assaf; Werner M Nau
Journal:  Front Chem       Date:  2019-09-13       Impact factor: 5.221

Review 2.  Recent advances in supramolecular antidotes.

Authors:  Hang Yin; Xiangjun Zhang; Jianwen Wei; Siyu Lu; David Bardelang; Ruibing Wang
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

3.  Cucurbituril Ameliorates Liver Damage Induced by Microcystis aeruginosa in a Mouse Model.

Authors:  Na'il Saleh; Saad Al-Jassabi; Ali H Eid; Werner M Nau
Journal:  Front Chem       Date:  2021-04-14       Impact factor: 5.221

  3 in total

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